ID A0A3Q1EUF2_9TELE Unreviewed; 695 AA.
AC A0A3Q1EUF2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Fermitin family member 2 {ECO:0000313|Ensembl:ENSAPOP00000008761.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000008761.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000008761.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR AlphaFoldDB; A0A3Q1EUF2; -.
DR STRING; 80966.ENSAPOP00000008761; -.
DR Ensembl; ENSAPOT00000002700.1; ENSAPOP00000008761.1; ENSAPOG00000010988.1.
DR GeneTree; ENSGT00390000013444; -.
DR InParanoid; A0A3Q1EUF2; -.
DR OrthoDB; 5399911at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0055008; P:cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd17181; FERM_F0_KIND2; 1.
DR CDD; cd17184; FERM_F1_KIND2; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF11; FERMITIN FAMILY HOMOLOG 2; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT DOMAIN 389..485
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 141..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..158
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 79667 MW; F63843C4320B40EF CRC64;
MALDGIRMPD GCYADGTWEL KMHVTDLHRD VSLRVTGEIH IGGVMLKLVE KLDVKKDWSD
HALWWEKKKT WLLKTHWTLD KYGIQADARL LFTPQHKLLR LQLPNMKHMK VKVNFSDRVF
KAVSDICKTF NIRHPEELSL LRKPRDPKKK KKKLEEAEED DLELEGPLLT PGSASEIIYI
GPVKGSIYSS PGLYSKTMTP TYDSRDGSPL SPTSAWFGDS PLSEGNPSIL AVSQPISSPD
ILVKLYKPQS LLDKAKINQG WLDSSRSLME QDVKENEVLL LRFKYHSFFD LNPKYDAIRV
NQLYEQAKWA ILLEEIECTE EEMMMFAALQ YHINKLSIMS SDNHMNNSEK EVDEVDAALS
DLEITLEGGK TSNTLGDITS IPELADYVKV FKPKKLTLKG YKQYWCTFKD ITISCYKSKE
EAHGTPAHQM NLRGCEVTPD VNISGQKFNI KLLIPVADGM NEIWLRCDTE KQYAHWMAAC
RLASKGKTMA DSSYNLEVQN ILSFLKMQHM NPDPPSIEPI TTDINPECLV SPRYLKKYKN
KQPGYIRDLI SARILEAHQN VAQMSLIEAK MRFIQAWQSL PEFGITHFLA KFQGGKREEL
IGITYNRLIR MDASTGDAIK TWRFSNMKQW NVNWEIKMVT VEFADEPSLS FICAEVDCKV
VHEFIGGYIF LSTRAKDQNE SLDEEMFYKL TSGWV
//
