ID A0A3Q1EUX8_9TELE Unreviewed; 1850 AA.
AC A0A3Q1EUX8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000007978.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000007978.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR Ensembl; ENSAPOT00000004034.1; ENSAPOP00000007978.1; ENSAPOG00000010602.1.
DR GeneTree; ENSGT00940000156088; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 9.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 13.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 13.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 14.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 12.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 450..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1502..1521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..92
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 93..182
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 343..433
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 601..688
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 774..874
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 955..1042
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1043..1131
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1132..1229
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1230..1321
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1575..1835
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1750..1826
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1850 AA; 203467 MW; 18676103EFACE689 CRC64;
DHLEVQPDPV HSGSGLWVSW SRSVGHVDRY DVSLEDSSSG SVLRTTVMDS AAPQSGFFSL
TPGTRYTVSV VASSGTKTSS PVQTSAATGE TDHLSSVGLA SLSPDVLSVS WRAGPGRVEN
FRVLLTDQDE VLLKNITLQN MSSSAELDGL QPGTPYTVTV VTEAAGLQSS ASTQVTTAPA
PVSGLVLDSA GSSDILRASW VSPAGRLDSY LVVLWAPGSA PQRHRLQPNT TQVEFEGLTP
GRSYQLSVSS SAVPAPVSGL FLSADSRELQ LSWTPPAGDW ESYSVVLRNG SEVLVNRTVG
KLSRRHVFSV LDLGLLPGRL YNAEVTVHSG ILGNRAACSA RIAPHPVQLS VRQADETSLS
VLWTQPAGHW DGFTALLRQM DQILDQRNLS WDATGVSFTG LTAGRRYTIN VTTSSGDLTS
SASVTAWTST SAAACVSVVG LCVCGWCLCL WFVCLCVGVC VCGWCVCLCG WCVCLWLVFV
SVVCVSVCWC VCLWLVCGSV WLVCVSVVGC VCLSVVGLAS NNGRTDFLIV SWRPAAGEVD
SYLVTLSDGE RTLHTLSVAE SSPSCVFSSL VSGRNYNICI SSCSGPHQNH SCIQERTQPA
KVQSPTATHA ARDDYLKVYW RPAAGDLDRY QVFIKHNNMF LQNQTVSKNQ SECVFTDLVP
GRLYTVLVNT WSGKYETSTS THGRTLPAPV RSLVLAGRGP EDLRVSWSAA PGDVDHYEVQ
LLFSDMKVFP PITLSAAVDH CLLTSLTPGR LYKVLVSTFS GPNQRARFIE GRTVPSKVKN
IQVSNHGDSS SLQVNWTPGP GDVDGYSVFL FRNGRQLSVR TVLKHQNQVT FGSLQPGQVY
DVTVQSVSGD LLNNHTDTGR TVPSAVTRLQ VDPLQSTCSL QVSWQDALGV ADRYVLQVLD
DRGILVTNGS QPFGQTWYRF HDLTPGKKYR VLVQTSSGGV HSPGVSAEAR TRPAAITDLI
LRSNSTKSLR FTWTPPVGEF QLYELYLYGA DDSLQERRSL QPGSLQSSFQ GLRPGAAYRL
VVLIRSGDQT NQTSMWARTV PAAVASLQLH TGNQSDVLVV NWDRGGGDLS GYLLTLYNPN
GSQQAEQRLG PDATEFVFSG LVPGRHYRAE VLSLSQELSN WAGAVGRTAP RPPSSFLFGS
VTNTSVEVTW SGPVDSDYDD FELRWTPEDR LSVINPYHSR TAGSRILKGL FPGRRYTFRL
RTVSGPLGAT EAPPTYSTAI WSSIRTKPER VQSLHCRPQS STSISCSWGP PEADYDSYTI
ECLHQDSRTL VYSRRTNRDS TSYVITQLEP HKHYTISVKV ISDRTTSEEA TDSVITMIDR
PPRPPISTRV SGLAVVVGRT FISFSFNCSW FSDANGAVRF FTVVVAESEG VENLQPDQHH
PLPSYLDYRS NSSIRTYQTS YFPSRCADSK ANSFDIGLGT GMDSLGGPCD QLDPESGTDP
TPFCDGPLKP RTSYRLSIRA FTQLFDEETK DSSNSFPLYT DTFLSLPVVT DAEPLSGVIE
GISAGLFLII MMVGITALLV CRYRARTHTR LPSVRMNVRR DRGTAGVQLG IRGPIKISNF
ENHYSKLQAD SHYLLSEEYE DLKDVGRNQP LDTALLPENR GKNRYNNILP YDSTRVKLSY
VDDDPCSDYI NASYIPGNNF RREYIATQGP LPGTKDDFWK MVWEQNVHNV VMVTQCVEKG
RVKCDHYWPF DQEPLYYGDL IVQMVSESVL PEWTIREFSI CSEEQLSFSR LVRQFHYTVW
PDHGVPETTQ SLIQFVRTVR DYVNRSPGSG PTVVHCSAGV GRTGTFIVLD RVLQQLDSKD
VLDIYGAVFD LRLHRSHMVQ TEGQYSYLHQ CLRDVIRARK LHSEQEHLRI
//
