ID A0A3Q1EVC5_9TELE Unreviewed; 788 AA.
AC A0A3Q1EVC5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Cadherin 18 {ECO:0000313|Ensembl:ENSAPOP00000007712.1};
GN Name=CDH18 {ECO:0000313|Ensembl:ENSAPOP00000007712.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000007712.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000007712.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
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DR AlphaFoldDB; A0A3Q1EVC5; -.
DR STRING; 80966.ENSAPOP00000007712; -.
DR Ensembl; ENSAPOT00000004478.1; ENSAPOP00000007712.1; ENSAPOG00000009755.1.
DR GeneTree; ENSGT00940000157512; -.
DR InParanoid; A0A3Q1EVC5; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 4.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF106; CADHERIN-18; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..788
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018713361"
FT TRANSMEM 604..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..160
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 161..269
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 270..384
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 385..489
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 489..604
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 685..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87678 MW; 18B2671522009CBB CRC64;
MRISTTSCLC PFLVCLCFIQ RSYGASHHIP TKVPSKNQTK LANGETEVHH RPKRGWIWNQ
FFVLEEHMGP DAQYVGKLHS NSDKGDGSVR YILSGEGAGT IFIINEETGD IHATKSLDRE
RKTHYVLHAQ ALDRNTEEAL EPKSEFIIKV QDINDNAPKF PDGPFVATVP EMSEVGTSVL
QVTATDADDP TYGNSARIVY SILQGQPYFS VDPKTGIIRT ALANMDREAR EHYTVVIQAK
DMAGQVGGLS GSTTINITLT DVNDNPPTFP QKNYQLYVPE SAQVGKPVGK IKANDEDLGV
NADIKYSIIN SEGANTFSIS TDRDTREGII SLKKPLNYER KKTYTLHIEG TNTHVDPRFS
YLGSFKDTTT LKITVGDVDE APIFSMDYYI LDVYENAPSG TEVGAVTARD PDSRNSPVRY
FLDSKEEGVR YFRIDEGSGL VRTTQPLDRE AMPWHNITVM ASEVDSPSLF SHVPVTVQVL
DVNDNPPEIA TDEEVIVCES SRQDHVIQTI TAVDKDDFAN GQRFSFALPP PVNPNFTLKD
NEDSTASIIA RRRRFNHLTQ ELYELPIVVW DGGEPSLSGT STLTLRVCPC QRHSKVRMCQ
GEAFLSSAGL STGALIAILL SIVVLFITLR RSKKEPLIIS EEDIRENVVT YDDEGGGEED
TEAFDIIALR NPAAAEELKF RRDVRPETRK HVDPPRSRRS PSMELDEVDV HEFIKQRLVE
ADMDTSVPPY DSLQTYAYEG QGSPTGSISP LDSPGTQSEQ DYNYLDDWGP EFQKLAELYG
EAESDVTT
//
