ID   A0A3Q1EWA2_9TELE        Unreviewed;      1148 AA.
AC   A0A3Q1EWA2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Rho GTPase-activating protein 39-like {ECO:0000313|Ensembl:ENSAPOP00000008409.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000008409.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000008409.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1EWA2; -.
DR   STRING; 80966.ENSAPOP00000008409; -.
DR   Ensembl; ENSAPOT00000003332.1; ENSAPOP00000008409.1; ENSAPOG00000010541.1.
DR   GeneTree; ENSGT00940000164502; -.
DR   InParanoid; A0A3Q1EWA2; -.
DR   OrthoDB; 5480623at2759; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04389; RhoGAP_KIAA1688; 1.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR45876; FI04035P; 1.
DR   PANTHER; PTHR45876:SF4; ZGC:92107; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00456; WW; 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF51045; WW domain; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          48..75
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          748..907
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000259|PROSITE:PS51016"
FT   DOMAIN          955..1143
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          92..185
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          331..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          387..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          665..701
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..294
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..348
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        387..425
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1148 AA;  126707 MW;  23AD05BFB1BA9728 CRC64;
     MSGTSADWVE ILEPRSRERM YVNLTTGECG WDPPPGVPVR QADGNQWWEL FDPHSGRFYY
     YNSTGRRTVW HRPQGADIVP LSQLQAMKRC SEAKQAGGGV ERHHHGTTGS ISSVGSQGRC
     TPLPEQDSDS LVPRALEPNE ETANPELDPA VESRSQGDGS STEHSTDSCK EPQRDASQRW
     QPAPGSKAAM LVKVNSMTRG QPNQAMQQHL QHSAHSKANT FTLHPTSNKA QGGHLNSAQG
     YKTAPSGKMA GDSRQAHHLR KASNGSFCLV TSDNSQPSPL LHRSQTSTPR PVSPQYGCTA
     PIYDEPVSEC PIYDEPPTDM EVEGAHLYNG QPLSRLTPTQ SLQKPRHLQH PGSSHPGSRH
     RRNPSSSDYS PAGLECIKHM VNVDPKQGLL SSSPVPTRAP SPTSKLDNVL IQPQPHPQPQ
     AHSLQHARGQ MRDRESGNPG PSSLDKKQNW RVLEATVQRA MEARHSRQSS QASQDFPSST
     PQATANYQDS GYSTGPSPSL RRKSRRRVGA GGGTGGRPGS VGSSGELSAL NERLMAEMRE
     VVSRSNTMRE VRAGLDPDMG ERVVVPRTRS PAGSLRWFGG GGAGSTGMCA SREDLTGASR
     SLKGAGNYGN PALTPLDIPG RQKRTYEKVD TLEMSVNSQA SLSSPETPGP PSQAGTLELQ
     AQLESRKKGM VDGRTASLGP HRSANHDSRE GGDGSGGRAG SAYQLSYATL RQPPPPDMGM
     EDWASKHLNM HTQGLFRRRV SIANMLSWNR GSIKKPMLVT SNRAVRKEAC EMFKLVQAYM
     GDRPSRLDRR HCALLIVTKC WDMPGLRDEL YVQLVRQTTG NASPRSLAAG WELMAVSLAF
     FAPSPKFRCY LEGYIQRHTE PTSDKKCESQ SEQQVTQFIL EQQELKLKKN SKSRKKRKQN
     TEEEEGLPIS TYAKFCHRKL QKVAITGGKK GLRKPTLEEI DHSRRAIVTP SLFGSSLEEV
     MERQSELFPD RKLPWVQVQL SQYVLALGGA QTEGIFRVPG DIDEVNALKL QVDQWRIPEN
     LSDPNVPASL MKLWYRELEE PLIPMNFYKQ CVSNCDDPVA AIAVVQSLPE LNRLVLCYFI
     HFLQVFAQPS NVAITKMDVN NLAMVMAPNC LRCQSDDPRI IFENTRKEMS FLRMLIVHLD
     TSFIEGVV
//