ID   A0A3Q1F077_9TELE        Unreviewed;       560 AA.
AC   A0A3Q1F077;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Acid sensing ion channel subunit 1 {ECO:0000313|Ensembl:ENSAPOP00000010143.1};
GN   Name=ASIC1 {ECO:0000313|Ensembl:ENSAPOP00000010143.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000010143.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000010143.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3Q1F077; -.
DR   Ensembl; ENSAPOT00000000346.1; ENSAPOP00000010143.1; ENSAPOG00000012549.1.
DR   GeneTree; ENSGT00940000158414; -.
DR   OrthoDB; 3415680at2759; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR004724; ENaC_chordates.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00859; ENaC; 1.
DR   PANTHER; PTHR11690:SF292; ACID-SENSING ION CHANNEL 1B; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW   Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT   TRANSMEM        95..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        475..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   560 AA;  63592 MW;  867A78A999D36F25 CRC64;
     MPVRIMCTIS FSADDEPGRG YGKDGFDDHY KRVKKSYGDG DSQEYLDGSS QVDDYADEED
     NVSEVDDLAA FFSGCSLHGA NHVFVEDKKF GIRQGLWAVV FTLALSAFLY QVADRVIYYL
     QFDYITMLDE RVANNMTFPA VTICNYNFIR KSQMSYSDLI FMGPLLGFEE GMAPGFPLAP
     EPDRPPGSRF SLDEFYSRTR HRVEDMLLEC NFRGLECGPE NFKEIFTRYG KCYTFNSGQD
     GRPLLVTMKG GTGNGLELML DIQQDEYLPV WGETDETSFE AGIKVQIHTQ DEPPFIDQLG
     FGVAPGFQTF VSCQEQRLTY LPPPWGDCKA TPMDSDFFNT YSITACRIDC ETRYLVENCN
     CRMVHMPGDA PYCTPEQYKE CADPALDFLV ERDNDYCVCE TPCNLTRYGK ELSFVKIPSK
     ASAKYLAKKF NKTEQYIADN ILVLDIYFEA LNYETIEQKK AYELAGLLGD IGGQMGLFIG
     ASILTVLELF DYLYEVIKYK MCRCMKKKHK GRNNNDRGAV LSLDDVKRHA PCENLRTPST
     YPGNMLPHHP GQGNFEDFTC
//