ID A0A3Q1F868_9TELE Unreviewed; 417 AA.
AC A0A3Q1F868;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Nodal homolog {ECO:0000313|Ensembl:ENSAPOP00000013148.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000013148.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000013148.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3Q1F868; -.
DR STRING; 80966.ENSAPOP00000013148; -.
DR Ensembl; ENSAPOT00000032282.1; ENSAPOP00000013148.1; ENSAPOG00000015940.1.
DR GeneTree; ENSGT00940000163919; -.
DR InParanoid; A0A3Q1F868; -.
DR OrthoDB; 5393576at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..417
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018652317"
FT DOMAIN 286..417
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 199..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 47039 MW; C63A388DB4333DE1 CRC64;
MEVRVLAAFC TLFLCFGGAA ASTWGHRYHT GLESSLAFRN LSVNHRSRCP LYMMQLYRSF
RTADSSSSLA VNTDATQSDN LSAHRSDSVM SLIAKGCHQV GERWTVTFDM SSISTSELVQ
QAELQIRIPA FSASKQATVD LYHSRKQSCD LDGTSCLEEQ LFLGSFGTSP SSANSSWKVF
NVTALLKYWL YQGEEVLSQE ASGEPEREAG SGAGDEGKMT DNHPSKNLGL RQRKIHHPTT
NRVMMVVFSK QNRHQEGDPA YSLIHTAENS KYVTMDRVNS EGQSRRNKRN RMERMRVAAG
AAPTVTPAAE PVQKPLCRKV DMWVDFEHIG WDEWIVHPKR YNAFRCEGEC PTPLDESFHP
TNHAYMQSLL RHHHPDRVTC PSCVPTRLSS LSMLYYENDD LALRHHEDMI VEECGCH
//
