ID   A0A3Q1F8B2_9TELE        Unreviewed;       439 AA.
AC   A0A3Q1F8B2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Clusterin {ECO:0000256|RuleBase:RU000629};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000012539.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000012539.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the clusterin family.
CC       {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR   Ensembl; ENSAPOT00000006047.1; ENSAPOP00000006799.1; ENSAPOG00000008716.1.
DR   Ensembl; ENSAPOT00000020460.1; ENSAPOP00000012539.1; ENSAPOG00000015276.1.
DR   GeneTree; ENSGT00530000063668; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000753; Clusterin-like.
DR   InterPro; IPR016015; Clusterin_C.
DR   InterPro; IPR016014; Clusterin_N.
DR   PANTHER; PTHR10970; CLUSTERIN; 1.
DR   PANTHER; PTHR10970:SF2; CLUSTERIN-LIKE PROTEIN 1; 1.
DR   Pfam; PF01093; Clusterin; 1.
DR   SMART; SM00035; CLa; 1.
DR   SMART; SM00030; CLb; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..439
FT                   /note="Clusterin"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5041078067"
FT   DOMAIN          22..225
FT                   /note="Clusterin N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00030"
FT   DOMAIN          210..426
FT                   /note="Clusterin C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00035"
FT   COILED          52..103
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   439 AA;  49856 MW;  6E55048FEBAEC810 CRC64;
     MVLVLLVEIL CIAVVGLCAA DSPPLREETL KKLSAAGEQY VDEEIKQTLL GVKQMKEMME
     KKEEKHRHLM DALRHSSDKK KLAKETKQKL DEAEQKCRDL TKSSFGKCRP CVEESCKAFY
     TSTCRRGFAS FSFKVEEFFR KMATQLEASE HVYNQNQENP DRTSSAETSF SQLLSNISLL
     YDHSVTVIQK MQQVFGRSFQ ASFTSELQPG LLSAVQGEPS AGFLRTVGLD HIFDSVFDFG
     KNVAEKFSSS IADVFEEIHE AEEYLQQGGY LCRQLRRQAS ECWQLQNLCE TCKDYLLKEC
     PSVQPLHSEM EEMNMLLNAS RQQYDDRLQL VQRHTADTQK WLSSMEDKFG WISQLSSSTV
     EPKSIFSVIS VNPQQRMRNN KPKAESTVVV SILDSTPITV LVPADLEVDD PAFIQFVAQE
     ALTLHKRQIK GNDPTSETL
//