ID A0A3Q1F8X2_9TELE Unreviewed; 820 AA.
AC A0A3Q1F8X2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=ABR activator of RhoGEF and GTPase {ECO:0000313|Ensembl:ENSAPOP00000003690.1};
GN Name=ABR {ECO:0000313|Ensembl:ENSAPOP00000003690.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000003690.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000003690.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR AlphaFoldDB; A0A3Q1F8X2; -.
DR Ensembl; ENSAPOT00000011326.1; ENSAPOP00000003690.1; ENSAPOG00000005363.1.
DR GeneTree; ENSGT00940000153491; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08686; C2_ABR; 1.
DR CDD; cd04387; RhoGAP_Bcr; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF5; ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 50..243
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 260..418
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 443..572
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 606..806
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 820 AA; 94247 MW; 9BDA5996EF0AF1BF CRC64;
MEEEEEEALC YLDRVLEEDE EVFDYGDGEL EPITPIHRQF KGDIEKGLEM KKLVLSGFLA
SEEIYINQLE ALLLPMRPLK ATATTSQPVL TIQQIETIFY KIQDIFEIHK EFYDALLPSI
QQWDEKVTVG HLFQKLASQL GVYKAFVDNY KVALETAEKC SQANIQFQKI SENLKVKGPK
DSKECTTSTS MEALLYKPID RVTRSTLVLH DLLKHTPKDH PDFPLLQDAL RISQNFLSSI
NEEIDPRRTA VTTPKGEARQ LVKDGFLVEV SESSRKLRHV FLFTDLLLCA KMKKTAVGRH
QQYECKWYIP LADLTFQTLD DSDSCPSIQV LPEHEIEEMK IKISVLKSEI QKEKKAPKGQ
SRVERLRKKM NEQESWLLLH SPTIPFRIHN KHGKSYLFLL SSDYERSEWR ESIQKLQKKD
LQACVLSSVE LQVLTSSCFK LRTVHNIPVT SNKDDEETPG LYGFLHVIVH SAKGFKESAN
LYCTLEVDSY GYFVSKAKTR VFRDTTEPQW NEEFEIELEG SQYLRILCYE KCYDKSMLNK
DDNEIVDKIM GKGQVQLDPQ TVQSKNWHMD VIEMNGIKVE FSMKFTSRDL SLKRTPSKKQ
SGVFGVKINV VTKRERSKVP YIVRQCIEEV EKRGIDEVGI YRISGVATDI QALKLAFDTN
TKDILVMLSD MDINAIAGTL KLYFRELPEP LLTDRLYPAF MEGIALSDPA AKENCMMHLL
RSLPDPNLMT FLTLLEHLKR VADKEPINKM SLHNLATVFG PTLLRPSESE STKGQHITSA
SDIWSHDVMA QVQVLLYYLQ HPPISFAELK RNTLYFSTDV
//