ID   A0A3Q1F936_9TELE        Unreviewed;       877 AA.
AC   A0A3Q1F936;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Epithelial cell transforming 2 {ECO:0000313|Ensembl:ENSAPOP00000014316.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000014316.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000014316.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1F936; -.
DR   Ensembl; ENSAPOT00000022697.1; ENSAPOP00000014316.1; ENSAPOG00000017184.1.
DR   GeneTree; ENSGT00940000156299; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR   CDD; cd17733; BRCT_Ect2_rpt1; 1.
DR   CDD; cd17732; BRCT_Ect2_rpt2; 1.
DR   CDD; cd01229; PH_Ect2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 3.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR026817; Ect2.
DR   InterPro; IPR049396; ECT2_BRCT0.
DR   InterPro; IPR049395; ECT2_PH.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR   PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR   Pfam; PF00533; BRCT; 1.
DR   Pfam; PF21243; ECT2_BRCT0; 1.
DR   Pfam; PF21242; ECT2_PH; 1.
DR   Pfam; PF12738; PTCB-BRCT; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF52113; BRCT domain; 2.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          141..220
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          236..324
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          419..608
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          359..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   877 AA;  99367 MW;  39164FD3BFFFBAAD CRC64;
     MADSSIVTLG TARSLLVDSS VYDSRIAETT KDHVFLGMTC EDGEDMLPKV ETRVVLVGEA
     GRNGALVKAL QDINTPFIMT DNIQEFADGE NTDFETVFVL KDFDSPDYSY LYKRDNRIVG
     PPVVLHCAAK EEPLHFSCRP LYSTTMLNVS LCFTGFRNKE EMKNLVNLVH HMGGTIRKDF
     STKVTHLIAY STHGEKYRLA VCMGTPILTP SWIHKAWERR DDVHFHAGEE EFRTGFKVPP
     FQDCILSFLG FSEEEKTNME ERTLKHGGGY LEVGDERCTH MVVEENSVKE LPFSPSQKVF
     VVKQEWFWGS IQMDARAGES MYLYEKNDSP AMKKAVSLLS LTTPNSNRKR RRLRDTLAQL
     TKETEISPFP PPRKRPSAEH SMSIGSLLDI SNTPETCKAL AESSKPSKSS TPVLSKQSAR
     WQVSKELYQT ESNYVDILST ILQLFKLPLE KEGQVGGPIL AQEEIKTIFG SIPDIYEVHT
     RIKSDLEELL SDWSESRSVG NIILKYSKEL VKAYPPFVNF FEMSKDTIVR CEKQKPRFHA
     FLKINQAKPE CGRQTLAELL IRPVQRLPSV ALLLNDIKKH TSDDNPDKIT LEKAIESLKE
     VMTHINEDKR KTEGQKQIFD VVYEVDGCPA NLLSSHRSLV YRVETIALGD QPCDRGEHVT
     LFLFNDCLEI ARKRHKVINT FKSPLGQTRP PPPLKHIALM PLSQIRRVLD LQDTEECVNA
     FALVVHPPTE QENLLFSFQL TGEETVKSAW LRTLCRHVAN TICRADAEDL IQCTDPDSLQ
     VSTKDMDSTL SKASRAIKKT SKKVTRVFSF TKTPKRVIQR AFLANTTPDE KSQRLSIENR
     VGSSSTLAAR HSPSMVNLPS MFERRYHTFS HSSSHLI
//