ID   A0A3Q1FAB0_9TELE        Unreviewed;       513 AA.
AC   A0A3Q1FAB0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN   Name=TTYH1 {ECO:0000313|Ensembl:ENSAPOP00000013234.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000013234.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000013234.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tweety family.
CC       {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR   AlphaFoldDB; A0A3Q1FAB0; -.
DR   Ensembl; ENSAPOT00000021340.1; ENSAPOP00000013234.1; ENSAPOG00000000449.1.
DR   GeneTree; ENSGT00950000183060; -.
DR   InParanoid; A0A3Q1FAB0; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424:SF5; PROTEIN TWEETY HOMOLOG 1; 1.
DR   PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR   Pfam; PF04906; Tweety; 2.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU361114};
KW   Chloride channel {ECO:0000256|RuleBase:RU361114};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|RuleBase:RU361114};
KW   Ion transport {ECO:0000256|RuleBase:RU361114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT   TRANSMEM        45..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        107..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        273..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        301..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        451..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   REGION          81..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  56161 MW;  F9EBE6F88B37925A CRC64;
     MAAMTTVPSY APSLWVRVCH ALPRLDLTMQ MRDNVFVPDS WEYQQTLLVL SSLSAIALVV
     SLLVILSFLI HYCCCHRGDR SEGSEEEEED EDGSTGHGYS GKKGRGICCV TWVAVAAVTL
     CCVAIGIGFY GNSEANDGMY QLTSSLLTAN YTLASIDLLI SDTISGLQLS VSGPLSSMEE
     LFTGSKPFLV STRNCRRLSE NVINLLSSIS LSRSGLDAGL GNDSGVSGAS ITPLTPVPPS
     VAPTMVPSGG LMPNPFSPGW AANTLMVNED YRWLSYVLLL LLDLIVCLFI LLGLAKQARW
     LLILMTVLAW LALFLSWGSL GLETATVVAL SDFCSDPNAF VLNSTQFSSG TSADVLDYYL
     TCSRRMNSPF QQLLTQSQRA LSNIHTHLSS LERNALPQFP KAEKSLREVQ QILNSTEGNF
     HQLVALLNCR GLNKDYIDSL KGLCYDGMEG LLYLSLYSFL SALAFTAILC SLPGAWRSFP
     SESEEYEDSD SESEDPFTSH QDSKRFLQWQ PWL
//