ID   A0A3Q1FAI9_9TELE        Unreviewed;       531 AA.
AC   A0A3Q1FAI9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Cdc42-interacting protein 4 homolog {ECO:0000313|Ensembl:ENSAPOP00000014841.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000014841.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000014841.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC       {ECO:0000256|ARBA:ARBA00004544}. Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}. Lysosome
CC       {ECO:0000256|ARBA:ARBA00004371}.
CC   -!- SIMILARITY: Belongs to the FNBP1 family.
CC       {ECO:0000256|ARBA:ARBA00009426}.
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DR   AlphaFoldDB; A0A3Q1FAI9; -.
DR   Ensembl; ENSAPOT00000032991.1; ENSAPOP00000014841.1; ENSAPOG00000017829.1.
DR   GeneTree; ENSGT00950000183047; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd07653; F-BAR_CIP4-like; 1.
DR   CDD; cd11628; HR1_CIP4_FNBP1L; 1.
DR   CDD; cd11911; SH3_CIP4-like; 1.
DR   Gene3D; 6.10.140.470; -; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR011072; HR1_rho-bd.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15735:SF17; CDC42-INTERACTING PROTEIN 4; 1.
DR   PANTHER; PTHR15735; FCH AND DOUBLE SH3 DOMAINS PROTEIN; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS51860; REM_1; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW   Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          1..264
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          335..412
FT                   /note="REM-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51860"
FT   DOMAIN          469..530
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          417..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          106..203
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          342..409
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   531 AA;  61128 MW;  ECCB06A456734D27 CRC64;
     MDWGTELWDQ YDIIEKHTQS GLELVEKYVK FVKERTEIEQ NYAKQLRNLS KKYNLKRSSK
     DEPECRLSSY QSFLDIVNEM NDYAGQRELI AENLMMNICI DLTKYLQELK QERKTYLMEA
     KKAQQSLEST YKQLDNSKKR FEREWREAER AAQYAEKTDQ DINATKADVE KAKQQAHMRA
     HVAEECKNDY AAQLQKYNKE QNQFYFTDMP LIFNKLQDLD ERRVQKLAQG YILFSDTEKH
     VMPIIGKCLE GITKAGTNVN EKNDSMVVIE QNKSGFERPG DLEFEDYSQG INRASSDSSL
     GTPKGPMDLL GKNKSKNFWL FSKKSKPTVT EDFGHLPPEQ RRKRLQQKLE EICKELQKEV
     DQSEALGKMK DVYEKNPQMG DPASLASQIN QTSQNIERLR AELNKYETWL AEAGGRGDTL
     RHKTQTFNNN GAHDMHSPDG AHSDESTPDA SQAIYAEFDD DFEDEEVTAP IGKCTAMYNF
     PGASEGTISM QEGEVLAVVE EDKGDGWTRV RRNNGDEGYI PTSYVTINLN K
//