ID A0A3Q1FBV1_9TELE Unreviewed; 905 AA.
AC A0A3Q1FBV1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000013372.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000013372.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR AlphaFoldDB; A0A3Q1FBV1; -.
DR STRING; 80966.ENSAPOP00000013372; -.
DR Ensembl; ENSAPOT00000021547.1; ENSAPOP00000013372.1; ENSAPOG00000016210.1.
DR GeneTree; ENSGT00950000182815; -.
DR InParanoid; A0A3Q1FBV1; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF4; NETRIN RECEPTOR UNC5A; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 35..905
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5025084501"
FT TRANSMEM 367..391
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 164..246
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 504..647
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
SQ SEQUENCE 905 AA; 100763 MW; E32E5515775955D1 CRC64;
MKMPSLLGPF VRCRFSATLL VLWLAFAGFT CTAGSEHTAT ATLPAAFSDL LPHFLVEPED
EYIVKNKPVT LTCRSTPATQ IYFKCNGEWV HQDDHLIERT VDPATALPVM QVTIDITRQQ
VEKIFGLDEY WCQCVAWSTT GTQKSQKAYI RIAYLRKNFE EEPQGKEVAL DQEVLLRCHP
PEGVPQAEVE WQRNEDVIDP ASDPNFFITT DHNLVIKKAR LADTGNYTCV AKNIVARRKS
TSATVLVYVN GGWSTWTTWS SCSAVCGRGW QKRSRSCTNP TPLNGGTSCE GQNVQKSACV
ATCPVDGGWS EWSKWSACGA DCSMWRTREC TQPSPGTGGK ECQGLDLQSL NCTSEQCPQT
VSGAEDVALY VGMVAVALCL TLLLIVVVLV YRRKKEGLDA DVADSSILTT GFQPMGIKPS
KPENSHLLTI QPDLTTTTTS YQGTLRSRHD ATGKFSMTNG PLLDPLPNGS HSLHNGKLNS
DPAEFVSRLS TQTYFKTLPR DVANTSYGTF NFLGGRLTIP STGISLLIPP EAIPRGKIYE
IYLTVQRKED LRLPLAGCQT LLSPVVSCGP PGVVLSRPVI LSMDHCFDAC LDNWAVRLKK
QNYEGVWEDV LLMGEELVSE PYYCQLEAET CRLFSEQLGT FALVGESLHM GAAKRLRLVL
FSDAYCSTLE YNIRVYCMDD TQDVFKEVMQ MERQLGGRLI DEPHVLLFKD SYHNLRLSIH
DMPQAHWRSK LLAGYQEIPF YHIWNGSQRY LHCTFTLERL SLSTCELTCQ LCVWQVEGEG
QSFSLDFNIA KDTRAVDSEF LLMDSNATAL AGPSAFQIPY LIRQKICSSL DAPCPNGADW
RMLAQRLKLE RHMSFFASKA SPTSVILDLW EAQHFHSGNI NQLATVMADI GKQEAMIFLV
SDGEC
//
