ID   A0A3Q1FCL2_9TELE        Unreviewed;       976 AA.
AC   A0A3Q1FCL2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Sorting nexin 25 {ECO:0000313|Ensembl:ENSAPOP00000014773.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000014773.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000014773.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   AlphaFoldDB; A0A3Q1FCL2; -.
DR   STRING; 80966.ENSAPOP00000014773; -.
DR   Ensembl; ENSAPOT00000032968.1; ENSAPOP00000014773.1; ENSAPOG00000017763.1.
DR   GeneTree; ENSGT00950000182856; -.
DR   InParanoid; A0A3Q1FCL2; -.
DR   OrthoDB; 5392990at2759; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06878; PX_SNX25; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037899; SNX25_PX.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        39..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          136..302
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          428..542
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          650..770
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   976 AA;  111379 MW;  2FEC59EA685AF5B0 CRC64;
     MPTPSTTTTP PAGGTSSTGG EEGPMSATST SSVGSSFRFV PAFCLGVVAA VVFQLAWGGL
     TLTSFFLKLF IYVSFALLCF LAGSFVLLVR KSPLKVSCFD RNRRQSAARL EFFNKLMGRF
     SVPVQETSQS RRVVVSHNVD KTLKEVFDYA YRDYILSWYV PLSRDEGQLC SMLSEDWWQM
     IGHLRSRLAN IDVVNVVCYD SIRILHTHFT DLKAASARPE ECARPFPLHP CLVSSDSEMA
     FLRCVARILL LCLLPQKDAK SHTLRCCLTE VITTKVLKPL VEVLSDPDSI NRMLLSQLEQ
     REQQAEQQKK AYTYAASYED FIKLISTSTD VNFLKQLRYQ IVVEIIHATT ISSLPQLKKQ
     KERKGKESAA MKADLLRARD MKRYINQLTV AKKQCEKRIR LLGGPNYENN EEGGADDGDE
     PQSQKILQFD DIMCNPGYRE HFRVYMERVD KRALISFWEL VETLKTANKN EVPQIVGEIY
     QKFFVESREI PVEKFLLKEI QQSLVGNRGT QVFVRLQEQV AETMRERYYP SFLVSDLYDR
     LIKRDDQHSQ SRCSTGEKEE GCQVLDVGEE VGDEGSKGIN EQASYAATKL RQLYDKLEYK
     RQALGSIQSA PKPDKKIVSK LKEEIGAMEK EHSELQQHIT RTDWWCENLG HWMATITTAE
     ATEEGGETVA SYSVCVSLVE GEETANSRWV VQRKLTEFQM LHRKLTECFP SLKKLQLPSL
     SKLPFKSIDQ KFLDKSKTQL NAFLQRLLND ERLCQSEALY AFLSPSPEHL KVMSIQKKSS
     FSLASFLERL PGDFFSHTEE DGDDDSDLSD YGDEADGRKD ALAEPCFMLI GEIFELRGMF
     KWVRKTLIAL VQVTFGRTIN KQIRDTVNWI FCEQMLVCYI SVFRDTFWPN GKLAPHVKVR
     TDSERSETKE RAQQKLLDNI PDALANLVGQ QNARYGIIKI FNALQEASAN KHLLYVLMEM
     LLKELCPELR AEMDTI
//