ID A0A3Q1FD43_9TELE Unreviewed; 1094 AA.
AC A0A3Q1FD43;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000014953.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000014953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q1FD43; -.
DR STRING; 80966.ENSAPOP00000014953; -.
DR Ensembl; ENSAPOT00000023495.1; ENSAPOP00000014953.1; ENSAPOG00000017878.1.
DR GeneTree; ENSGT00940000164854; -.
DR InParanoid; A0A3Q1FD43; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR45836:SF13; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 2.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 16.
DR SMART; SM00179; EGF_CA; 14.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 7.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 922..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..70
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 137..175
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 177..213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 215..251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 253..289
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 291..326
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 328..364
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 370..406
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 431..471
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 473..509
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 511..547
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 549..585
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 588..624
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 626..662
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 664..700
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 980..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 989..1007
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 28..37
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 41..53
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 61..70
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 165..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 203..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 241..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 279..288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 295..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 316..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 354..363
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 396..405
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 461..470
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 499..508
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 537..546
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 575..584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 614..623
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 652..661
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 690..699
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1094 AA; 119842 MW; 9DC2174C3A3F06F8 CRC64;
MINPGDHWQT ILHDGPVAHL MYRIRVRCDD NYYSNKCNKL CVPRDDYFGH YRCEPSGAQV
CLDGWMGPDC RTAICKQGCN LLHGGCSVPG GCKCNYGWQG QFCDECVLYP GCVHGTCNLP
WQCNCERNWG GLLCDKDLNY CGRHQPCING GTCMNTEPDE YYCACPQGYS GKTCQIAEHA
CVSSPCANAG TCHEVPTGFE CQCPPGWEGP TCANNLDECA SSPCAQGGTC VDLEDGFECV
CPPQWEGKTC QIDANECAEQ PCVNAYSCKN LIGGYHCDCF RGWSGLNCDI NVNGCHGQCL
NGATCKEGPK GYHCQCTSGF VGTHCAIQRN QCDSRPCQNG GQCHAVLDSF VCECPAEFAG
QLCEISTWSS SDACDPNPCE NEAQCHSMDQ DFYCACPEGY KGKTCERLKE NCQTTPCQVI
DSCTVAEATN DSAEVRHISS NVCGPRGHCI SQPAGNFTCI CDAGFSGVYC HENINDCISN
PCRNGGTCID GVNSFQCFCP DGWEGRLCDL NVNECRHNPC KNGGQCVDLV NDFYCECADN
WKGKTCHSRE SQCDETTCSN GGTCYDHGDA FRCDCPPGWE GNTCNTAKKS TCTSSPCSNG
GTCVGGGDTF TCICKEGWEG PSCGQNTNDC NPHPCYNGGI CVDGVNWFRC ECAPGFAGPD
CRININECQS SPCAYGATCV DEINGFRCIC PLGRTGTRCQ EFIGIGKTCH YAGLQFPHGS
HWEEECNTCH CINGKVDCTK VLCGRRPCRL QSAGQDQRQQ SCPAGRECLE HSYFTCFSPP
CHQWGVCSMA GPPPPQATTK CQPNNGHLDN SCGRVTLVFN RDKVPPGTTV ENICFELRYL
PDTQSLAKDH ALLLLCDLSH SNQDAVEVAI SFHPEDLPDH SLIQETASAI VGTLSKRHNS
TIMLAVIEVK VETQVMPPSV DYLVPLLCVV FCLLCLFCII VCVWWTRKRR KERERTTHSA
ADDNVNNQWE PLRLMVGRQQ QQQQQLKESN REAEQERKKL MGPSYRTCDE EEEEETDGEL
ELEECGGAEA GKQLVYKYSK TAVQSSGGVI CTLHSSSSPL KAPHRTQGYS PKDNRWKNVS
AVFNGQKDLR DHCV
//
