ID   A0A3Q1FDN6_9TELE        Unreviewed;      1374 AA.
AC   A0A3Q1FDN6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Ras/Rap GTPase-activating protein SynGAP-like {ECO:0000313|Ensembl:ENSAPOP00000014414.1};
GN   Name=SYNGAP1 {ECO:0000313|Ensembl:ENSAPOP00000014414.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000014414.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000014414.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   STRING; 80966.ENSAPOP00000014414; -.
DR   Ensembl; ENSAPOT00000022861.1; ENSAPOP00000014414.1; ENSAPOG00000017311.1.
DR   GeneTree; ENSGT00940000158438; -.
DR   InParanoid; A0A3Q1FDN6; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   CDD; cd04013; C2_SynGAP_like; 1.
DR   CDD; cd05136; RasGAP_DAB2IP; 1.
DR   CDD; cd22265; UDM1_RNF168; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR021887; DAB2P_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   PANTHER; PTHR10194:SF145; RAS_RAP GTPASE-ACTIVATING PROTEIN SYNGAP ISOFORM X1; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF12004; DAB2P_C; 2.
DR   Pfam; PF00616; RasGAP; 2.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          151..185
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          176..294
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          361..553
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          35..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          862..894
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          958..1107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1170..1229
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1374 AA;  154800 MW;  DEBDBE6431DF317C CRC64;
     MDTSSKTWLP HQSQFGLVGQ AEVCCGGPGV LTPNQSRRAS FASARQSSME TPPNTTPQPF
     RQPSFLNRRL KGSIKRAKSQ PKLDRTSSFR QMILPRFRSA DQERTRLMQS FKESHSHESL
     LSPSSAAEAL DLVLDEDAII KPVHSSILGQ EYCFEVTTNS GTKCFACRSA SERDKWIENL
     QRAIKPNKDN SRRVDNVLKL WIIEARDLPA KKRYYCELCL DDMLYARTTS KPRTDTVFWG
     EHFEFNNLPT IRSLRLHLYK ETDKKRRKEK STYLGLVSIP ISSITGRQFV EQWYPVIQSS
     VLAKSGGVGS AKVINASLRV KSRYQTMNIL PMELYKEFAE YITNNYRTLC AVLEPLLSVK
     SKEEVAFALV HILQSTGKTK EFLSDMAMCE VDRFMDREHL IFRENTLATK AVEEYLKLIG
     HRYLKDAIGD FIRALYESEE NCEVDPMRVP PSVLADHQAN LRMCCELLLC KIINSLCIFP
     RELKEVFASW RARCAERGRE DLADSLISSS LFLRFMCPAI MSPSLFNLMQ EYPAERTSRT
     LTLIAKVMQN LASFSKFGPK EEYMYFMNEF LEMEWGSMQQ FLYEISNMDT GGNAGGFEGY
     IDLGRELSML HSLLWEVMGQ LSKDAILKLG PLPRLLNDIS VALRNPQLHM PTNHQPDRPK
     DRLFSRPSFN RLMSSDFQSL MMRDLNSSID ISRLPSPTTG VSAVESLSSN LNMRRHAERD
     LRSSREVFYV TRPPLARSSP AYCTSSSDIT EPDPKVHSVN KSVSMMDLQD SRMNSISNLN
     SVGDMLTSSQ ASIAGLGHSF GNLGGPLRHL PAGSAGSGLR LSQMGHVGGP TESISQQQQQ
     AAAAMHFPLS FQNPLFHLAA QNSPAQSQQP PPPLLLAPEP ENGHHDYQPA FGNSAFSRSE
     DLSALRSQSS LVQPSIVHSH SYSDDFTRQN QSNDYAWHQL SLQVQESLQQ QHLMGVASQT
     GTGTGTPASL ATPPTTVHPV RQTSIAPQHL KSQRSINTAT PPKVRPQSRN LLLDSSDTNL
     HGSQPKSRQA QQPSQQQQQQ QQQQQQAQQQ QDVQLSVTDS PAPGLPYQTS STKENQGPPA
     AAEESTDTPT KSTKKPQSQL QPPQQHLLKP VVNKQGSQST LSTTAMNERT VAWVSNMPHL
     SADIESLRPD REGQLKEYSK SMDESRLERV REYEEEIHSL KERLKMSHRK LEEYEQRLLT
     QEQQTNKILQ QYQNRLDDSE RRLKQQQLEK DSQIKGIINR LMAVEDELRG GAIPDIKPRI
     LTDQVCACVY IFYHPYSLNQ SCPKTVCFIL ASHPEHFAKA SAGEKFAAVM PVTYSHLSKS
     TFVTSEIAFR HLPHMPEGGE NENSTDPQNQ ELDLCSEVNL VCHCEGIASL QRRS
//