ID   A0A3Q1FF11_9TELE        Unreviewed;       135 AA.
AC   A0A3Q1FF11;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Endothelin-1 {ECO:0000256|ARBA:ARBA00040197};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000005625.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000005625.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC       {ECO:0000256|ARBA:ARBA00010959}.
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DR   AlphaFoldDB; A0A3Q1FF11; -.
DR   Ensembl; ENSAPOT00000008036.1; ENSAPOP00000005625.1; ENSAPOG00000007345.1.
DR   GeneTree; ENSGT00950000183053; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR   GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR   InterPro; IPR020475; Endothelin.
DR   InterPro; IPR019764; Endothelin_toxin_CS.
DR   InterPro; IPR001928; Endothln-like_toxin.
DR   PANTHER; PTHR13874; ENDOTHELIN; 1.
DR   PANTHER; PTHR13874:SF10; ENDOTHELIN-1; 1.
DR   Pfam; PF00322; Endothelin; 1.
DR   PRINTS; PR00365; ENDOTHELIN.
DR   SMART; SM00272; END; 2.
DR   PROSITE; PS00270; ENDOTHELIN; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW   Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..135
FT                   /note="Endothelin-1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018649224"
FT   DOMAIN          45..66
FT                   /note="Endothelin-like toxin"
FT                   /evidence="ECO:0000259|SMART:SM00272"
FT   DOMAIN          99..120
FT                   /note="Endothelin-like toxin"
FT                   /evidence="ECO:0000259|SMART:SM00272"
SQ   SEQUENCE   135 AA;  15205 MW;  0B7394C741989478 CRC64;
     MDLYVFISVL SAMFSWISCT ALPAPVTDAP TASTGSLRPR VRNKRCSCAT FLDKECVYFC
     HLDIIWVNTP ERVVSYGLGN APRTRRALVD SMATSGAPRC RCLRENDATC GSFCGNRNLR
     RCVIYRERQE RTKRG
//