ID A0A3Q1FHC1_9TELE Unreviewed; 2084 AA.
AC A0A3Q1FHC1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Unconventional myosin-VIIb-like {ECO:0000313|Ensembl:ENSAPOP00000015287.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000015287.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000015287.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR Ensembl; ENSAPOT00000033165.1; ENSAPOP00000015287.1; ENSAPOG00000019103.1.
DR GeneTree; ENSGT00940000157247; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd17093; FERM2_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 3.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF24; UNCONVENTIONAL MYOSIN-VIIB ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 4.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS01179; PID; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2084
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018641741"
FT DOMAIN 77..741
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1003..1205
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1612..1762
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1768..2072
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1996..2025
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 629..651
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 170..177
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2084 AA; 239928 MW; 8CF740EC8D6A6E6C CRC64;
MKLQIPWSKF GFAAFTLIIL PLGDFVWVDS GAGVPLGAEV KVTDTGQLRL IDDEGKEHKI
NKKNEGSIRP MHPTSVKGVD DMISIGDLNE AGLLRNLLVR HKEGIIYTYT GSILVAVNPY
QLLPLYTTDH VHMYTDRRLG ELPPHVFALA DACFFNMRRN KKNQCCVISG ESGAGKTEST
KLMLQFLAAV SGQHSWIEQQ ILEANPILEA FGNAKTVRND NSSRFGKYID VNFTKGGAIE
GARVDQYLLE KSRVCRQAPE ERNYHIFYYM LMGMPADQKK ILSLGSAAEY KYLTMGNCTR
CEGRDDVKEF AHFRAALKIL MFTENDSWEI CKLLAAVLHI GNVEFEGTIV NNLEGCEIHR
SSHFDMACQL LEVDPNALDK SLTQRSFTTA RESVIKGLTS AQALDGRDAF VKGIYGRLFI
WVVDKINSAI YKPPEDENEV RPSIGLLDIF GFENFNINSF EQLCINFANE QLQQFFVKHV
FKLEQEEYSR ENIVWKHIDY QDNQRTLDVL AVKPLNMLSL IDEESSFPKG TDSTMLQKMN
QLHGKGDIYI PPKNNYETQF GIQHFAGVVY YDSEGFLEKN RDTLSLDLIQ LVETSGNKLL
KQAFHNELST GSNTIKSMPT LVGQFRQSLD ALMKALTACQ PYFIRCIKPN DFKKPMLFDR
ELVMRQLRYS GMMETIRIRK AGYPVRYTFD EFLNRYRVLL KKKCCESICE SMLSGKGDWK
TGKTKIFLKD FHDTMLEVER IKELNHKALL IQKVMRGFKF RREFLRKRAA AIMIQKHWRG
HKGRKLYKVV QLGFARLQAQ VRSRQLHFQY KRQREAALVL QAQIRGYLAR KDWKRKRDAA
ILLQAQTRGM LARKALKKMK RDVTNWNSLR SQKFINDNIQ NMYLSAKEKE EEQRLALQRQ
KHLEEVLRKK REEEEKAQSA AISAEEIVDD IFGFLPSIVG GQEGQAPVGF ENLEGKRRTF
EEIDIDDIPM EEDLSKDDYD DLDEYSFSKF ASMYFQGAAT PTHIRQRLLQ PLLYHEDEGD
ILASLTVWWI ILRFMGDLPE PKKQVNVQAA SRREQFMPQE LVSRADRRFS NMHVCLVLCL
LYNTDPDVMI GEGPTLDRPL TSLEKLHIIV GYAIVRRDLR DEIYCQICKQ LQDNKNRNSY
FRGWILMSLC LGVFPPTEPF QKYLQSFIRS APRGYASYCA NRLRRTVMNG MRGEPPSWLE
LQATKTLQPM IVTVTLLDRR SINLPVDSAT TSREICQLLA SKVKLIDTFG FSLYVALYEK
VWALGSGREH VMDAISQCEQ EVKKRGGQEQ HAPWRLLLRK EIFTPWHNCK EDKISTDLIY
RQIIHGLKFG EYQTEKVEAV QDCINNRLLE AKSEAKWTQM ISTAHAQVKK ADSVKAEMVD
YAREKWPIFF SRFFEVTKLS GPLPKSKFIV AINWTGITFL DEREKRLLEL SFPEVTAVNS
ISQGKSSEQT VSLLTLKGDF TLTGSTVEDM SELITMFLSG LKERSRYAVA LKDVDRGPSK
GELIILIKDD EFSEQRGWVK GQRENLKHTG AVPIEAILIL PTLSKPSNEV MSLLTLTPNQ
RKTILQTMQK ETATMERMAP FSLKEFSHQY FRYLEMLSVI SRNAAPERLW VSSREPIRQP
LLMKLVGNSE FSPKACLTFT DILYTRYMGD YPTRQIQSPL ELTDQIFGPA TQHEALRDEI
YCQIMKQMTN NNNRFSMEQG WQLLWLCCGL FPPSQALLKH AQRFLESRRR MPMASDCLQR
LQSSLRYPRK FPPHQVEVDA IQQNSTQIFH KIHFPNDTDE IFEVSTSTRI RDLIQSISKK
LGLASADGFS IFVKTHDKVL SLNDTDYFFD SLRQITDWSK RAKRIRDGGG PLNISYLVFF
MRKLWFNVIP GRDTEADLIF HFPQEMPKYL RGFHVCTKED MINIAGLLFR VKVGSDKSQV
AMIPKMIKDL VPADQLKAMS ENEWKKGIAA SYNKYAGFTV EEAKVAFLKA ICRWPTFGCA
FFEVKQTSEQ NFPDIVRISI SKQGVTVINP KTKDVLATHP FNRIANWSSG STYFHMTVGN
LVKGNKFLCE TSLGYKMDDL IASYVNMYNR ERRAMQTRNQ RFDM
//
