ID A0A3Q1FJ03_9TELE Unreviewed; 1202 AA.
AC A0A3Q1FJ03;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 1-like {ECO:0000313|Ensembl:ENSAPOP00000017916.1};
GN Name=RASGRF1 {ECO:0000313|Ensembl:ENSAPOP00000017916.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000017916.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000017916.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1FJ03; -.
DR Ensembl; ENSAPOT00000034233.1; ENSAPOP00000017916.1; ENSAPOG00000021288.1.
DR GeneTree; ENSGT00940000157599; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 240..426
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 467..586
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 633..748
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 967..1199
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 711..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 150..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 718..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1202 AA; 137891 MW; 7329722925246BDF CRC64;
MQKGMRLNDG HITYLALLAK KDGTRRGCLS KKSSDNTKWH SKWFALLQNM LFYFENDSSS
RPSGLYLLEG SVCDRAPSPK PSLSAKECLE KQYYFTVTFN HDNQKALELR TEDVKDCDEW
VAAITQASYR NLATEHETLM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKSEIAG
LLKDNEKIQS NPEVPPSEDD TEIKKIKKVQ SFLRGWICRR KWKTIIQDYI RSPHAESMRK
RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS
RIMHDEVSET ENIRKNLAIE RMIVEGCEVL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG
SLSLKKEGER QCFLFSKHLI ICTRGSGGKL HITKNGVVSL IDCTLMEEPE GTDDESKGER
SGQDTEHLDF KVMVEPKDSQ PYTVILVASS RQEKSAWTSD ISQCIDNIRC NGLMMNAFEE
NSKVTVPQMI KSDTSLYCDD VDIRFSKMMN SCKVLQIRYA SVERLLERLT DLRFLSIDFL
NTFLHSYRVF TSADVVLDKL ITIYKKPISA IPARSLELFF ASSQNNKLLY GEPPTSPRAS
RKFSSPPPLS ITKTSSPNRR RKLSLNIPII TGGKALDLAA LSCSPNGYAS MHSTMSPFSK
TTLDINKLYV SSTMASKISD EGDSKTEGKT DESVLNKQGQ NLSVREECNE DPSQSDDAEA
EMSPPKSPST PKNVKSKNSG FPTDQRNGDK EFVIRRAATN RVLNVLRHWV SKHSQDFELN
TELKMRVIGF LEEVMHDPEL LTQERKAAAN IIRTLTQEDP GDNQVTLEEI TQMAMEDCKT
EPFESHSALE IAEQLTLLDH LVFKVIPYEE FFGQGWMKND KNERTPYIMK TTKHFNDISN
RIATEILQWD DVNMRVAVIE KWVAVADICR CLHNYNAVLE ITSSLNRSSV FRLKKTWLKV
SKQTKTVIDK LQKLVSSEGR FKNLREALKN CDPPCVPYLG MYLTDLAFIE EGTPNYTEDN
LVNFSKMRMI SHIIREIRQF QQTAYKIDYQ PKVAKYLLDS STVLDEESLY EASLRIEPKT
SS
//
