ID   A0A3Q1FK55_9TELE        Unreviewed;       477 AA.
AC   A0A3Q1FK55;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Islet cell autoantigen 1 {ECO:0000313|Ensembl:ENSAPOP00000017518.1};
GN   Name=ICA1 {ECO:0000313|Ensembl:ENSAPOP00000017518.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000017518.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000017518.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1FK55; -.
DR   STRING; 80966.ENSAPOP00000017518; -.
DR   Ensembl; ENSAPOT00000026811.1; ENSAPOP00000017518.1; ENSAPOG00000000589.1.
DR   GeneTree; ENSGT00390000005530; -.
DR   InParanoid; A0A3Q1FK55; -.
DR   OrthoDB; 5317533at2759; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR   CDD; cd07661; BAR_ICA69; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR010504; AH_dom.
DR   InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR   InterPro; IPR006723; Islet_autoAg_Ica1_C.
DR   PANTHER; PTHR10164; ISLET CELL AUTOANTIGEN 1; 1.
DR   PANTHER; PTHR10164:SF3; ISLET CELL AUTOANTIGEN 1; 1.
DR   Pfam; PF06456; Arfaptin; 1.
DR   Pfam; PF04629; ICA69; 1.
DR   SMART; SM01015; Arfaptin; 1.
DR   SMART; SM01237; ICA69; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS50870; AH; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          53..256
FT                   /note="AH"
FT                   /evidence="ECO:0000259|PROSITE:PS50870"
FT   REGION          270..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          364..388
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          417..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..301
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..388
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..437
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   477 AA;  53983 MW;  44362DEE1D8BB362 CRC64;
     MEGGNFGYSR DYLDRFIQSQ DSSVVNKFQQ KYWKTKQTLI KVTGKKEDEH VVASDADLDA
     KLEVFHSIQR TCMELLKVIE QYQRRICLLS QEENELGRFL RSQGSQDKTR AGKIMQATGK
     ALCFSSQQRL ALRNPLCRLY QEVETFRYRA ISDTWLTVNR MEQSRTEYRG ALLWMKDISQ
     ELDPDTHKQM EKFRKVQAQV RTTKTSFDKL KNDVCQKVDL LGASRCNLLS HVLTTYQTTL
     LHFWEKTSHT MAAIHESFKG SQHYEFSTIK TLQDPTDKPA KKKGKKKPKA ESEDGKKAET
     TDDQLISLQI NENENTSDKT REDLLSADPE VEGEEKDSMA LLNEILGGLS VDDGDFSREW
     TEVFGETEEG TSAASGRPAE SQQKENSFFL PSQLLDQSLN NLQSSVSDWA GIIPQPVTQA
     TEHSSGANQN PSKPAVKDAT GTSKDLSAWF NLFADLDPLS NPDAVGKSDT EHELHNA
//