ID   A0A3Q1FLH9_9TELE        Unreviewed;       731 AA.
AC   A0A3Q1FLH9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=MutL homolog 1 {ECO:0000313|Ensembl:ENSAPOP00000017284.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000017284.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000017284.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   AlphaFoldDB; A0A3Q1FLH9; -.
DR   STRING; 80966.ENSAPOP00000017284; -.
DR   Ensembl; ENSAPOT00000026553.1; ENSAPOP00000017284.1; ENSAPOG00000020464.1.
DR   GeneTree; ENSGT00800000124177; -.
DR   InParanoid; A0A3Q1FLH9; -.
DR   OrthoDB; 5475669at2759; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03483; MutL_Trans_MLH1; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR032189; Mlh1_C.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF16413; Mlh1_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          213..332
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   REGION          390..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..462
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   731 AA;  82129 MW;  F7931BF1375FBD55 CRC64;
     MAGVIRRLDE TVVNRIAAGE VIQRPANAVK EMIENCLDAK STSIQVTVKD GGLKLLQIQD
     NGTGIRKEDM EIVCERFTTS KLQTFEDLSA IATYGFRGEA LASISHVAHV TITTKTADAK
     CAYRANYSDG KLKGPPKPCA GNQGTQILVE DLFYNVSTRR KALKSPSDEY SRIVEVVSRY
     AIHNSGKSFS VKKQGETVAD VRTLPNASVV DNIRGVFGNA VSRELIEVGC EDQKLAYKMK
     GYISNANYSV KKCILILFIN HRLVESSALK KAIETVYAAY LPKNTHPFLY LSLEIAPQNV
     DVNVHPTKHE VHFLHEDSVI ESVQKHIESK LLGSNSSRTY FTQTLLPGLS ISGGTEVKAP
     SATAESTERV YAHQMVRTDS RAQKLDAFLQ PKEKPPPDPE PAGPSRKDSV TKTVQPDVVE
     MDDADLLEAL GQREAEEPKG EEENSVAAHD VQRKRPRKEQ TEQEDEDEDP TVAASPKRRV
     IKLTSIKELR AEISENTHKG LQEMLQNHSF VGCVSPQWTL IQHHTKLYLL NTTKLSQELF
     YQILIYDFGN FGVLRLSTPA PLYDLAMLAL DSEESGWTED DGPKEGLAQY IVDFLKKKAE
     MLEDYFSVEI DQEGNLTGLP LLLDKYTPVM EGLPMFILRL ATEVNWDNEK DCFRDFSKEC
     SMFYSIRKQY ILEAEPGEEQ DAEVNCWRWK VEHVIFKAFR SLFSPPKDFS EDGSVLQIAN
     LPDLYKVFER C
//