ID A0A3Q1FSN6_9TELE Unreviewed; 569 AA.
AC A0A3Q1FSN6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Solute carrier family 2, facilitated glucose transporter member 12 {ECO:0000256|ARBA:ARBA00039241};
DE AltName: Full=Glucose transporter type 12 {ECO:0000256|ARBA:ARBA00042905};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000021261.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000021261.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose(out) = D-glucose(in); Xref=Rhea:RHEA:60376,
CC ChEBI:CHEBI:4167; Evidence={ECO:0000256|ARBA:ARBA00000618};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm,
CC perinuclear region {ECO:0000256|ARBA:ARBA00004556}. Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004127}.
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DR STRING; 80966.ENSAPOP00000021261; -.
DR Ensembl; ENSAPOT00000016728.1; ENSAPOP00000000516.1; ENSAPOG00000000024.1.
DR Ensembl; ENSAPOT00000016732.1; ENSAPOP00000021261.1; ENSAPOG00000000024.1.
DR GeneTree; ENSGT00940000159614; -.
DR OrthoDB; 2013244at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0044381; P:glucose import in response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0003179; P:heart valve morphogenesis; IEA:Ensembl.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR48023; D-XYLOSE-PROTON SYMPORTER-LIKE 2; 1.
DR PANTHER; PTHR48023:SF2; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 12; 1.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..529
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 61385 MW; A35ADC8D0EFFF7EF CRC64;
MMDHKPETQK MTTYLPGSPT SETQRLAPPT RPGCSWLVVM AAVAASLSGL MLGYEMGLTS
GVLLQLRGVL SLSCREQELL VGSHLLGALL ICLAGGPILD HYGRRCSLLL SAALVVGGTV
VLVAVTSLAA LTLGRLIVGM GTALSGTAAC LYIAEISPRE RRGLLVTLYE LMLVVGVMLG
FGCSYAFASL PRGWTYTFGL VVPPALLQIG ALLFLPLSPR FLVAQGRVEQ AKVVLARLRG
GVSDQVEAEL RDIQVGLKEE SEHSFWELFS SKANLRLRLL TGIALVFLQQ ATGQPNILSY
ASPLLRSVGF NSDAAATLAS TGFGVVKVVF TVPAVLLVDR VGPKSFLCVG AVAMGMSLAT
LGTLTLQSHT HLTSLCKSHT HLNHTHLLWD LNRTVLDQND LDLYSTQLPP EWISEEVARA
EDQSGGRTHM EVSSSLKWAS LISLLLYVAA FSISLGPMVY VVLSEIFPMG VRGRAVSVVS
AVNWATNLLI SMTFLTITEK IGVPNIMFLY AAMSFVLLVF VILCVPETKG RTLEEISKEL
AKKKNFQLRI CRKVQPKESL IRIKSPAVV
//
