ID A0A3Q1FTG3_9TELE Unreviewed; 622 AA.
AC A0A3Q1FTG3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000021566.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000021566.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q1FTG3; -.
DR Ensembl; ENSAPOT00000015937.1; ENSAPOP00000021566.1; ENSAPOG00000002230.1.
DR GeneTree; ENSGT00940000164418; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24044:SF308; DELTA-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 6.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 6.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..189
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 256..294
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 296..332
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 334..371
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 373..409
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 411..447
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 449..485
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 147..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 160..172
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 180..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 284..293
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 322..331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 361..370
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 399..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 437..446
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 475..484
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 622 AA; 68129 MW; DAB889E7B554C321 CRC64;
MLFPLQVVSS GVFELKIHSF HTAQRICRRH RDCHIFFRIC LKHPEDVISA EPPCTFGTGQ
TNVIRADHTS ISSSAPIRVP FHFKWPGTFS LIIEAWNAES PTEYTDNQNN LVSRLATRRR
LAIGEDWSQD VHFGEQSELR YSYHVFCDEY YFGDGCADYC RPRDDTLGHY TCDEEGNRIC
LEGWKGNYCS EPICSADCSE RHGYCEAPGG CTCRMGWQGP SCNECVRYPG CLHGTCSQPW
QCNCQEGWGG LFCDQDLNYC TNHKPCANGA TCTNTGQGSY TCTCRPGFGG TNCELETNEC
DSNPCKNGGS CNDLENDYSC TCPQGFYGKN CEIIAMTCAD GPCFNGGTCV ETMTGGYTCR
CPSSYTGSNC EKKLDRCSNR PCLNGGECLD LGQSILCRCQ AGFTGANCQV NIDDCASSPC
QNAGTCQDGV NDYTCSCTLG YTGKNCSVRS DACGARPCQN GGTCFTHFTG PVCQCPKGFM
GPSCEFTLQP SFKPALRQAS QPTSTTVTIS CILAILVMVL VAGILFLRRR RRMQGRKQLS
DIAVYNDLET VNNLGGNERE AFLGPNGLFK ISNSTARLSL SLCPDGRSGY RHNPVESSLA
RGERQDFMWR DEGGLGSGAG LR
//
