ID A0A3Q1FVT5_9TELE Unreviewed; 1911 AA.
AC A0A3Q1FVT5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Receptor-type tyrosine-protein phosphatase F {ECO:0000256|ARBA:ARBA00044158};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000022456.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000022456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSAPOT00000013755.1; ENSAPOP00000022456.1; ENSAPOG00000003809.1.
DR GeneTree; ENSGT00940000155060; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 7.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR CDD; cd14629; R-PTP-F-2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF7; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00014; FNTYPEIII.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 8.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1911
FT /note="Receptor-type tyrosine-protein phosphatase F"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018685160"
FT TRANSMEM 1262..1285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..126
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 138..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 241..323
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 330..420
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 425..519
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 523..612
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 617..714
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 719..827
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 828..921
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 926..1018
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1021..1105
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1356..1611
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1531..1602
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1643..1902
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1820..1893
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 406..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1911 AA; 213480 MW; F304EECD27F0D843 CRC64;
MVHNIHLAVP LLPRWALLFL LLLSCVVFSS VADSLPSFVK SPEDQTGISG GVASFVCQAT
GEPKPRITWM KKGKKVSSQR FEVIEFDDGS GSVLRIQPLR THRDEAIYEC TATNSAGEIN
TSAKLTVLEE NQIPHGFPTI DMGPQLKVVE RTRTATMLCA ASGNPDPEIS WFKDMLPVDI
SSSNGRIKQL RSGGTPIRGA LQIENSEESD QGKYECVAMN SAGTRYSAPA NLYVRVRRVP
PRFSIPPTNQ EVMPGGSVNL TCVAVGSPMP YVKWTMGQTE LTKEEEMPMG RNVLEVTNIR
ESANYTCVAI SSLGMIEATA QVTVKALPKP PTSLIVTETT ATSVTLTWDS GNPEPVSYYM
IQYKAKSSDN GFQEVEGVAT TRYSIGGLSP YSEYEFRVMA VNNIGRGPPS DPVETRTGEQ
APSSPPLHVQ ARMLSASTML VQWGPPEEPN GQIRGYRVYY SSDLTAPLSA WQKHNTDDSS
LTTISGLTPD ITYSLRVLGF TSVGDGPPSD ILQVKTQQGV PAQPSSFEAE AELDTRIVLT
WLWPVQDPIT KYELQYWEAG SENKIHKTFN PAGSYAVEGL KPDTLYRFSL AARSEMGLGV
YTQPIEARTA QSTPSAPPQE VHLVSLSSTS LKVSWVAPPA ASRHGAIVRY SISYQALAGE
DMERFEVTGI GAEATSYVLD GLEKWTEYQV WVRAHTDVGP GPESAPVKMR TKEDVPGAPP
RKLEVEAINS TAIRVTWKPP MQGKQHGQIR GYQVIFSRLE NGEPRGQPNI MDVALPEAQW
NIEESTEHEA IIGGLQSETT YSVTVAAYTT KGDGARSKAK VITTTGAVPG KPTMMISTTM
GNTALMQWQP PKEMVGELMG YQLQYKRTDE ETYTSRELRK TDDHYTVTGL HKGATYIFRL
SARNRAGIGE AYVKEISTPE DVPSGFPFNL KVTGLTQSST QLTWEAPLLA ERNGKIIYYV
VVYRDINSQQ NSTNRTAYTN MTINGLNPDT TYDIRVQAFT SKGGGPLSPS IQSRTMSNDF
PTLNFGVKAV MKTSVLLTWD LPPNYKPQAP FKILYNQQSV EVQGNLKRKL ITQLQPDTDY
SFVLTSRGNI AGGLQQQVSI RTAPDLIKTK PSTHQAQGGK MTINLPKVQT TTRVRWYYIV
VMPVSQATRQ LNNPDEMDLD ELLKSSEGPV LRRRRHLDSS KPYIAAKLAS LPVSFTLGDE
KRYNGFYNKP LTSQQEYLCF VLAALRYEGT DNTANYMTFS ASPYSDPIQV TPSPQGMEQP
EMLWVMGPVL AVVLIVIIVI AILLFKNKQE RKRASPLPKD EHSGGVKDSL LANSSDPVEM
RRLNYQTPGM REHPPIPVVD LADHIERLKA NDSLRFSQEY ESIDPGQQFT WENSNMEVNK
PKNRYANVIA YDHSRVVLTS VDAVPGSDYI NANYIDGYRK QNAYIATQGP LPETLSDFWR
MVWEQRSSTI IMMTRLEEKS RVKCDQYWPS RGTETYGMIQ VTMLDTVELA TYSVRTFALY
KNGSSEKREV RQFQFMAWPD HGVPEYPTPI LAFLRRVKAC NPPDAGPMVV HCSAGVGRTG
CFIVIDAMLE RMKHEKSVDI YGHVTCMRAQ RNYMVQTEDQ YIFIHEALLE AATCGNTEVP
ARNLYAHIQK LTQAPPGETV TAMELEFKRL ANSKAHTSRF ISANLPCNKF KNRLVNIMPF
ESTRVCLQPI RGVEGSDYIN ASCIDGYRQQ KAYLATQGPL AETTEDFWRM LWEHNSTIVV
MLTKLREMGR EKCHQYWPAE RSARYQYFVV DPMAEYNMPQ YILREFKVTD ARDGQSRTIR
QFQFTDWPEQ GVPKTGEGFI DFIGQVHKTK EQFGQDGPIT VHCSAGVGRT GVFITLSIVL
ERMRYEGVVD LFQTVKTLRT QRPAMVQTED QYQLCYRAAL EYLGSFDHYA T
//
