ID   A0A3Q1FXB5_9TELE        Unreviewed;       940 AA.
AC   A0A3Q1FXB5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000021958.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000021958.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC       repulsion of neuronal growth cones in the developing nervous system
CC       upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the unc-5 family.
CC       {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR   AlphaFoldDB; A0A3Q1FXB5; -.
DR   STRING; 80966.ENSAPOP00000021958; -.
DR   Ensembl; ENSAPOT00000014977.1; ENSAPOP00000021958.1; ENSAPOG00000002879.1.
DR   GeneTree; ENSGT00950000182815; -.
DR   InParanoid; A0A3Q1FXB5; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.220.30; -; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR037936; UNC5.
DR   InterPro; IPR033772; UPA.
DR   InterPro; IPR000906; ZU5_dom.
DR   PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR   PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   Pfam; PF17217; UPA; 1.
DR   Pfam; PF00791; ZU5; 1.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SMART; SM00218; ZU5; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50092; TSP1; 2.
DR   PROSITE; PS51145; ZU5; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU367033};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW   ECO:0000256|RuleBase:RU367033}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Signal {ECO:0000256|RuleBase:RU367033};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT   CHAIN           28..940
FT                   /note="Netrin receptor UNC5"
FT                   /evidence="ECO:0000256|RuleBase:RU367033"
FT                   /id="PRO_5025093414"
FT   DOMAIN          156..238
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          529..670
FT                   /note="ZU5"
FT                   /evidence="ECO:0000259|PROSITE:PS51145"
SQ   SEQUENCE   940 AA;  103589 MW;  89440513BDB3003E CRC64;
     MGQFSGGCYL TFSIFVLLGL RVPATLARGP RGEALQHGQS GTLPHFLEEP VDAYIVKSNP
     IKLRCQARPA LQIFFKCNGE WVHQSQHMSQ EHTDLGTGLK IREVMINVSR QQVEDFHGPE
     DYWCLCVAWS HLGTSKSRKA TVRIAYLRKN FEQDPQGTEV PLNGMIVLHC RPPEGVPVAE
     VEWLKNEEPL SFDDDGISDS RGDHNLIISE ARLSDSGNYT CVASNIVAKR RSATATVVVY
     VNGGWSSWTD WSPCNVRCGR GVQKRSRTCT NPAPLNGGAF CEGMSVQKST CNTVCPVDGS
     WGEWSEWSLC SSECERQRSR ECTAPEPKHG GRLCDGVALA TDNCTGGLCT QNRKLLHDAK
     PQGVETSSDV ALYSGLAAGV VTVVLLIVAV TLYRRSQSEY GVDVIDSSAL TGGFQSFSFK
     TSRQANPLLI NSSMQPDLTV SRTYTSPMCF QDSIDKELMA ERSLLDPLPD LKVKGATERA
     EYHVMSHPQT FPRGLAPDYR GVAVGTTLGR RGKNLFAPQV SLTPSWPLHK ATAVFGHAGG
     RLMVPNTGIS LLVPHGGIAE DTTWEMYMSI NQEDSSAVSE DGPEIFLSAA VMYGPPGLDL
     SCPIAMTIAH CAEVAADNWT IRLKRHIQDN KWEEVMSVDE ESTSSYCLLE AQRCHVLLEH
     PGRYALVGEP LNQEAAKRLR LAVFGSPDTS NSLGFTLRVY CVDDTPHAFQ EVAVGERSRG
     GRLLEEPKIM LFRGNTFSLQ VSIQDVPQLL WSIKPFTTCQ EFSFSQVWAS NQRPLQCAFS
     LERYSHSSSQ LSCKISIRQV TGEEQILQVY TSVVENEKGV VPFFTQSDCT ITSQTGSRAF
     KIPLSIRQRI SATFDTANAN GKDWQLLAQK LHIDRNLCYF ACQESPSSVI LSLWEAQHQD
     SGDLDSLASA LEEIGKVQSP RAAMLPCSKE ERDSEFTKLG
//