ID   A0A3Q1FXN3_9TELE        Unreviewed;       786 AA.
AC   A0A3Q1FXN3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=DAB adaptor protein 2 {ECO:0000313|Ensembl:ENSAPOP00000022083.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000022083.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000022083.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1FXN3; -.
DR   STRING; 80966.ENSAPOP00000022083; -.
DR   Ensembl; ENSAPOT00000014665.1; ENSAPOP00000022083.1; ENSAPOG00000003052.1.
DR   GeneTree; ENSGT00940000155567; -.
DR   InParanoid; A0A3Q1FXN3; -.
DR   OrthoDB; 2913989at2759; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IEA:Ensembl.
DR   GO; GO:0030510; P:regulation of BMP signaling pathway; IEA:Ensembl.
DR   CDD; cd01215; PTB_Dab; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR048559; DAB1/2_SBM.
DR   InterPro; IPR048561; Dab_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   PANTHER; PTHR47695:SF5; DISABLED HOMOLOG 2; 1.
DR   PANTHER; PTHR47695; PID DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF21792; DAB2_SBM; 1.
DR   SMART; SM00462; PTB; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01179; PID; 1.
PE   4: Predicted;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   DOMAIN          61..198
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          552..628
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          724..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        14..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..422
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        432..450
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        552..573
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        592..606
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..742
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   786 AA;  82429 MW;  D4B20E8553186CF0 CRC64;
     MSAEVENSTP VAADPGLASM TTGSTSAPNS PSTAASRVPF KKEKKKVPEK TDEYLLGRFQ
     GDGVRYKAKL IGIDDVSEAR GDKMCQDSMM KLKGMAVAAR SQGKHKQRIW INISMSGIKI
     IDERSGVIEH EHVVNKISFI ARDVTDNRAF GYVCGAEGQH QFFAIKTAQQ AEPLVVDLKD
     LFQVIFNMRK KETEAPQKGE NGSTVVENGN DAVLSTASGA KAAQPVEQLD LFGDMSTPPD
     IRAPNDSNDI LLLDFSDELD SNQNCIKGNP LVNSCAPDYR ASPHTENPFS STFGYFPAPD
     SDPFRDDPLS KPPARLAPDN AQISLTNHLN STTGSTSKTI INGGLNGDSE PLSQQINGLS
     SKTMILALSN GQWPLGGKIT QGSTITMMDG NESGLVLSTK NPFFDSSLKT SPVSNGTSHR
     PEPPVTHSKD SVLINPPPQN SKSGRGRRSA KASSSDLFGE ELFAAPSQSE GSSASADLFN
     STPTNSSSIA ALGNLQLGLP ATTSIPTATM WGPTPAAPNM FSMPGVAVPG PRPAYPQPSA
     FGGLPIPPTA WGHPMQPPFS PPPLSPPHLA WSQPPVTNPF QPGAFPGMGD QQGPSRPPPR
     PPAKEAPPKV ENSAFTALDP LGDKEKKTGK DMFKDFQLAK PPAIPARKGE LVSGSAPASG
     SKEAGAFDQY FSSKVGVAQD SADHDDFDIK QMSLANDVPK AAPAPAAAPA PNFNAGLLDA
     AFSSAPVSNN SAPSQGQGLN QDMFDQAFGA PDSSPFGVPP VAMNASVGQS SGSTGAFGDA
     FGNPFA
//