ID A0A3Q1G017_9TELE Unreviewed; 750 AA.
AC A0A3Q1G017;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Prickle planar cell polarity protein 3 {ECO:0000313|Ensembl:ENSAPOP00000023058.1};
GN Name=PRICKLE3 {ECO:0000313|Ensembl:ENSAPOP00000023058.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000023058.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000023058.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC {ECO:0000256|ARBA:ARBA00008268}.
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DR AlphaFoldDB; A0A3Q1G017; -.
DR Ensembl; ENSAPOT00000012218.1; ENSAPOP00000023058.1; ENSAPOG00000004669.1.
DR GeneTree; ENSGT00940000153629; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09415; LIM1_Prickle; 1.
DR CDD; cd09418; LIM2_Prickle; 1.
DR CDD; cd09420; LIM3_Prickle; 1.
DR CDD; cd09827; PET_Prickle; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR033725; LIM1_prickle.
DR InterPro; IPR033726; LIM2_prickle.
DR InterPro; IPR033727; LIM3_prickle.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033723; PET_prickle.
DR InterPro; IPR047120; Pk/Esn/Tes.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24211; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24211:SF19; PRICKLE PLANAR CELL POLARITY PROTEIN 3; 1.
DR Pfam; PF00412; LIM; 3.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 3.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
DR PROSITE; PS51303; PET; 1.
PE 3: Inferred from homology;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 7..115
FT /note="PET"
FT /evidence="ECO:0000259|PROSITE:PS51303"
FT DOMAIN 117..181
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 182..242
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..503
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..530
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..577
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..686
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..726
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 750 AA; 84136 MW; 1493607FBDD3C178 CRC64;
MMTKLVSDFQ RHSISDDDSG CASEEYAWVP PGLKPEQVYQ YFSCLPEDRV PYVNSLGERY
RIKQLLHQLP AHDSEPQYCN SLDEEEKKEL CLFSQQRKRE NLGRGIVRLF PVTMTGAICL
QCGRQICGGD IAVFASRAGH SSCWHPQCFQ CASCSELLVD LIYFYQDGQI YCGRHHAERL
KPRCQACDEI ILADECTEAE GRYWHMKHFC CFECEAALGG QRYIMRESRP YCCSCYESLY
AEYCDTCGEH IGIDQGQMTY EGQHWHAVES CFCCARCRLP LLGRPFLPRG GLIFCSRPCS
LGEDPNNSDS CDSALQSRPP QHSRRSGTEK RQQLQCGSPL QPLEGIHPTV TTAKDCIHTA
VENKGVHCTA PVQNGLPSPS GHPHPRGSYS PLPHIHLGNG LGPSWPSDLP HYSLLPGDCT
VKPPVSDLQL QAELNGNAGL TGLNSRGTSA DKDCRNWVEK TNQVMQAFPP KKNSHMKQLI
SPDSPPLPPN NPSSLPPPLP VKSRDLMPRD SPPPALPQPD DRPSDPPPPL TRSSTARVSF
REPISSSYSV EEDEDEEGHQ EENQQEDEEE EEEEEEEGGF GSRLHLQKGI PPQMDLLDGS
SYQRRGPRRG WSRCRIPSDP ALHQSSERRS RRSRPDRPHL DTLDWRGEKE RDTRGSSNSS
SLTLQQGHYK HGDSCSTCSS SSDSEEEGYF LGKPIPVPPQ LRKQEPEGVK NREEDEVKEV
QRDKGLRGSI RRRRAHSLGA KDKDKNCAIS
//
