ID A0A3Q1G0A3_9TELE Unreviewed; 578 AA.
AC A0A3Q1G0A3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=THUMP domain containing 2 {ECO:0000313|Ensembl:ENSAPOP00000021332.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000021332.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000021332.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000256|ARBA:ARBA00008361}.
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DR AlphaFoldDB; A0A3Q1G0A3; -.
DR STRING; 80966.ENSAPOP00000021332; -.
DR Ensembl; ENSAPOT00000016584.1; ENSAPOP00000021332.1; ENSAPOG00000001802.1.
DR GeneTree; ENSGT00530000063557; -.
DR InParanoid; A0A3Q1G0A3; -.
DR OrthoDB; 5406466at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 240..350
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
FT REGION 114..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 63095 MW; A2CFC3391FF9C2E5 CRC64;
MAEPRSEEDV IRYFCTAGNG MEPFLMEEVK KKLAAEDVCQ LPGKVLFSSS AGIDKISDLK
AAERLFLLLK QDSPLRISAH TSSAKAASVL QYRLLGDKNQ WTGAVMTWSR LQGELAGSRT
TARTPSSALG LMIKIEEGRG SRGKEEEEGS CLVESRKSPE EQREEENGNE RLKSGEQNGT
RTLEKKRKRN HEEEEEEAER KNVEKGKSAE RGRRREEEAE TGMDVEFNSY HGTDVNQSTT
DLENNVESSS RTMDFTERLQ NGMNTCGDKD QTPLIVGKSK PELSSSIPVS FRISCKCTGS
LSRCFSAQEV SSVMGAGLSR LLGWKVDLKN PQLEINVYLG DDLCLLGIPL TRSPLAKRSY
IKTTGLRSTV AWAMTSLAHI QPGSRVIDPM CGAGTILIEA AQEHEAACFL GLDIDDGQLQ
KASENTAFAE LGHRIHLLKA SSLALPLTGS SVDAVICDLP FGRKFGTKTD MATNLPLILA
EMERVLCVGG TLVLLLSPQL SFLLKKVLTG PSSHQEAKPP PGTENSPSPS VCATKQQAKA
SPQLSLLPRL SSLRHEATFR VSLGAIDGLI HKYVKTEC
//
