ID A0A3Q1G2A2_9TELE Unreviewed; 1530 AA.
AC A0A3Q1G2A2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000021947.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000021947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2A subfamily. {ECO:0000256|ARBA:ARBA00010504}.
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DR Ensembl; ENSAPOT00000015069.1; ENSAPOP00000021947.1; ENSAPOG00000002897.1.
DR GeneTree; ENSGT00940000153617; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 4.
DR CDD; cd05738; IgI_2_RPTP_IIa_LAR_like; 1.
DR CDD; cd05739; IgI_3_RPTP_IIa_LAR_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF8; PROTEIN TYROSINE PHOSPHATASE RECEPTOR TYPE S; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1530
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018762022"
FT TRANSMEM 869..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..121
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..228
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 240..322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 329..419
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 424..520
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 522..616
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 618..702
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 977..1240
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1160..1231
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1272..1521
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1449..1522
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 903..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1530 AA; 171635 MW; A9DE16E55722FD08 CRC64;
MHVSTYPRMN SASPGLLLLS FLFLADADSP PRFTRTPEDQ TGVQGGVASF VCQASGEPQP
KIVWNKKGKK VSNQRFEVIE FDDGSGSVLR IQPLRTPRDE AIYECHASNS AGEITASTRL
SVLREDQLPS GFPTIDMGPQ LKVVERSRTA TMLCAASGNP DPEITWFKDF LPVNTSNNNG
RIKQLRSGGT PIRGALQIEM SEESDQGKYE CVATNSDGTR YSTPANLYVR ELREVRRVPP
RFSIPPADSE IMPGGNVNIT CVAVGSPMPY VKWMLGAEDL TPEDDMPIGR NVLELTDVRQ
SNNYTCVAMS TLGVIEAVAQ IIVKALPKAP GTPVVTERTA TSITLTWDSG NPEPVSYYII
QHRAKGSEDP YKEIDGIATT RYSVGGLSPY SHYDFRVAAV NTIGQGPSSD VVEARTAEQA
PSSPPRQVIG RMLSATTAMI HWDEPEEPNG QVVGYRVYYT SDNTLPVNQW EKQMVRSANF
ITIQDLTPNK TYYIRVLAFT SVGDGPLSQD LQIIAKTGVP SQPSEFKGEA KSETSILLSW
VAPTPQGGPD NQITGYELVY RRADDSEEKK VTFEPTASYL LKNLKPFSTY TFQLAAKSKN
GIGAYTNEVS IDTPQTLFAT NFRVKAAMKN SVLLSWEIRD KNPAQPFTIL YGKGQSVEVD
GKQTQKLITG LEPDTQYSFL LTNRANSAGG LQHRVTATTA PDILKTKPTV VGKTNADGMV
TVQLPTVQTT AKVRGYYVVV VPLKKQRGGK FLNPWEEPDQ MNLDELLKEI NRTSISRALR
IRRQAGQSDP RAYVTAHFKT LPMEFTLGDG RNYGDFRNRP LQNGQEYVFF VLALLDLSEN
TMYATSPYSD PVTSSDVDPQ PIVDEEEGLL WVVGPVLAVI FIVCIVIAIL LFKSKPDRKR
AEAEGRKGSF PCSKAMSSHH PTDPVELRRI NFQTPAYRVS VYRGYRRLSS MASHPPIPIS
ELADHIERLK ANDNLKFSQE YESVDPGQQF TWENSNLEVN KPKNRYANVI AYDHSRVILS
SIEGVPGSDY INANYIDGYR RQNAYIATQG SLPETFGDFW RMVWEQHTAN IIMMTKLEEK
SRMPSYFFSK VKCDQYWPTR GTETYGLIQV TLLDTVELAT YSVRTLALYK SGSNEKREVR
HFQFTAWPDH GVPEHPTPFL AFLRRVKACN PPDAGPMVVH CSAGVGRTGC FIVIDAMTER
IKHEKTIDIY GHVTLMRSQR NYMVQTEDQY IFIHDALLEA VTCGNTEVPA RNLYSYIQRL
TQIEPGENVT GMELEFKRLA SAKAHTSRFV SANLPCNKFK NRLVNIMPYE TTRVCLQPIR
GVEGSDYINA SFIDGYRQQK AYIATQGPLA ETTEDYWRML WEHNSTIVVM LTKLREMGRE
KCHQYWPAER SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ FQFTDWPEQG
VPKSGEGFID FIGQVHKTKE QFGQDGPITV HCSAGVGRTG VFITLSIVLE RMRYEGVVDI
FQTVKMLRTQ RPATVQTEVN FAPVVFLSRF
//
