ID   A0A3Q1G2J6_9TELE        Unreviewed;      1149 AA.
AC   A0A3Q1G2J6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Plexin-A1-like {ECO:0000313|Ensembl:ENSAPOP00000024003.1};
GN   Name=PLXNA1 {ECO:0000313|Ensembl:ENSAPOP00000024003.1};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000024003.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000024003.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1G2J6; -.
DR   Ensembl; ENSAPOT00000009842.1; ENSAPOP00000024003.1; ENSAPOG00000006293.1.
DR   GeneTree; ENSGT01050000244850; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   CDD; cd01180; IPT_plexin_repeat1; 1.
DR   CDD; cd01179; IPT_plexin_repeat2; 1.
DR   CDD; cd01181; IPT_plexin_repeat3; 1.
DR   CDD; cd12790; RasGAP_plexin_A; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR031148; Plexin.
DR   InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR   InterPro; IPR046800; Plexin_RBD.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR041362; TIG2_plexin.
DR   PANTHER; PTHR22625; PLEXIN; 1.
DR   PANTHER; PTHR22625:SF35; PLEXIN-A1; 1.
DR   Pfam; PF08337; Plexin_cytopl; 2.
DR   Pfam; PF20170; Plexin_RBD; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01833; TIG; 4.
DR   Pfam; PF18020; TIG_2; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SUPFAM; SSF81296; E set domains; 4.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        518..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          87..136
FT                   /note="PSI"
FT                   /evidence="ECO:0000259|SMART:SM00423"
FT   DOMAIN          137..233
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   DOMAIN          234..319
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   DOMAIN          321..420
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   DOMAIN          422..517
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   COILED          537..586
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1149 AA;  129096 MW;  2386E031AEC4E15F CRC64;
     MRPITLLAQN LPQPQSGQRN YECIFHIQGN THSVPALRFN SSSIQCQKTS YDYEGGDISD
     LPVDLSVVWN GNFVIDNPFN IQAHLYKCRA LRDSCGMCLK ADPRFECGWC VQDRKCSLRQ
     ECGGWMHATS GNSRCTHPKI TKLFPETGPR QGGTRVTILG ENLGLQFRDI QMGVRLGKVP
     CVPLEEEYVS AERIVCLLND ATGYRVQEAQ VEVCVRDCVN DYRALSPRPF TFVTPYFTRI
     QPSQGPISGG TRVTIEGSYL NAGSYVSVSI GPLPCYFKKR NAREIVCVTP AGLAPGSTSV
     LVDIDDAELR NPEVKFNYTE DPTVLRIEPD WSIASGGTLL TVSGTNLATI REPKIRAKYG
     QAESFHNCTV YNNSVMVCLA PSVADSELGF SETGTGPDEI GFYMDNVNAL VVVNETFSYY
     PDPVFEPLSP SGVLELKPTS PLILKGRNLI PAAPGNSRLN YTVLIGETPC ILTLSESQLL
     CEWPNLTGQH KVTIRAGGFE YSPGTLHIYS DSLLTLPAII GIGGGGGLLL LVIIAVLIAY
     KRKSRDADRT LKRLQLQMDN LESRVALECK EAFAELQTDI HELTQELDGA GIPFLDYRTY
     AMRVLFPGIE DHPVLKEMEV QANVEKALTL FGQLLTKKHF LLTFIRTLEA QRSFSMRDRG
     NVASLIMTAL QGEMEYATGV LKQLLSDLID RNLESKNHPK LLLRRTESVA EKMLTNWFTF
     LLYKFLKECA GEPLFMLYCA IKQQMEKGPI DAITGEARYS LSEDKLIRQQ IDYKTLTLHC
     VNPENENAPE VTVKCLNCDT ITQVKEKLLD AVYKGSPYSQ RPKASDMDLE WRQGRMARII
     LQDEDVTTKI DNDWKRLNTL AHYQVTDGSV IALVPKQNSA YNISNSSTFT KSLSRYESML
     RTASSPDSLR SRTPMITPDL ESGTKLWHLV KNHDHSDQRE GDRGSKMVSE IYLTRLLATK
     GTLQKFVDDL FETIFSTAHR GSALPLAIKY MFDFLDELLC FYLWLLKNNP QFVFDIHKNS
     ITDACLSVVA QTFMDSCSTS EHKLGKDSPS NKLLYAKDIP NYKNWVERYY SDISRMPAIS
     DQDMSAYLAE QSRLHLSQFN SMSALHEIYS YIIKYKDEIL SALQKDEQSR RQRLRGKLEQ
     VIDTMALAS
//