ID A0A3Q1G555_9TELE Unreviewed; 950 AA.
AC A0A3Q1G555;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 1 {ECO:0000313|Ensembl:ENSAPOP00000024059.1};
GN Name=HCN1 {ECO:0000313|Ensembl:ENSAPOP00000024059.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000024059.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000024059.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR AlphaFoldDB; A0A3Q1G555; -.
DR Ensembl; ENSAPOT00000009702.1; ENSAPOP00000024059.1; ENSAPOG00000006263.1.
DR GeneTree; ENSGT00940000158207; -.
DR OrthoDB; 74296at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF3; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 120..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 452..558
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 106162 MW; 7AFA6B9029598B4D CRC64;
MEDKSNSFSS NKEEKADGNN VFQRQDSIQK NNTGSQNMKD HGNSVGFKGE REEAMVGFDD
LEGASRQYGF MQRQFGAMMQ PGVNKFSLRM FGSQKAVEKE QERVQTAGYW IIHPYSDFRF
YWDLIMLIMM MGNLIIIPVG ITFFSEQTTT TWLVFNVASD TIFLVDLVMN FRTGIVNEES
SEIILDPKVI KMNYLKSWFV VDFLSSIPVD YIFLIVEKGF DSEVYKTARA LRIVRFTKIL
SLLRLLRLSR LIRYIHQWEE IFHMTYDLAS AVVRIFNLIG MMLLLCHWDG CLQYLVPLLQ
DFPPDCWVSL NGMVNVSWGK QYSYALFKAM SHMLCIGYGA RAPVSMSDLW ITMLSMIVGA
TCYAMFVGHA TALIQSLDSS RRQYQEKYKQ VEQYMSFHKL PADMRQKIHD YYEHRYQGKI
FDEDNILSEL NDPLKEEIVN FNCRKLVATM PLFANADPNF VTGMLSKLKF EVFQPNDYII
REGTVGKKMY FIQHGVASVI TKFNKEMKLT DGSYFGEICL LTKGRRTASV RADTYCRLFS
LSVDHFNEVL EEYPMMRRAF ETVAIDRLDR IGKKNSLLLQ KFQKDLNAGV FNTQENEILK
QIIRQDREMV MMVDRKQSVT GMNSTPMSGN SIINSPAQPP FSTAFGTNQL QQSSVPLTYS
ASAIANASAA RMLPVAAAAA AAAAQGIYPA PSVSHGNLNA SSTNPQTPLQ QQGAIMSPCS
FTAAMCSPPV QTPLANRSFQ YGSRTASQLS LIQQPIAQPS LPTQQQLVQQ PAVSTAAAAA
AVQQQQQQSP QQQQQQQQQQ QQQQQVPSPQ RGDIHKSTQA LQSGSLSRDV RHLSASQPSL
PHDTSLGPRA HPTSGDSLAS IVPPTAAAIQ GMSLQSGIRT TVPQRVNLFR QMSSGALPPV
RSAAAAAAAA AVAAASSSST QHRESPGSRR DSVLSSTETE QDKMRFASNL
//
