ID A0A3Q1GA51_9TELE Unreviewed; 1127 AA.
AC A0A3Q1GA51;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Solute carrier family 12 member 7-like {ECO:0000313|Ensembl:ENSAPOP00000024542.1};
GN Name=SLC12A7 {ECO:0000313|Ensembl:ENSAPOP00000024542.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000024542.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000024542.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q1GA51; -.
DR STRING; 80966.ENSAPOP00000024542; -.
DR Ensembl; ENSAPOT00000008496.1; ENSAPOP00000024542.1; ENSAPOG00000007115.1.
DR GeneTree; ENSGT00940000157657; -.
DR InParanoid; A0A3Q1GA51; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..272
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..302
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 416..696
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 710..828
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 836..969
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1045..1127
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1127 AA; 125094 MW; 1589817EEF751E2C CRC64;
MPTNFTVVPV KDNTRKADES NEEEDVDDNN VLKEEDEGTT GDGVPKENSP FINNTDNDKG
NSYDGTNMAL FEEEMDSNPM VSSLLNKLAN YTNLTQGAQE HEEADDDEGP KKKTIKSPQM
GTFMGVYLPC LQNILGVILF LRLTWIVGTA GILESLAIVG LCCSCTMLTA ISMSAIATNG
VVPAGGSYYM ISRSLGPEFG GAVGLCFYLG TTFAGSMYIL GTIEILLTYI VPKAAIFVAE
RKEDEVDALL NNMRVYGTCC LALMAVVVFV GVKYVNKLAL VFLACVILSI LAIYAGVIKT
IFEPPYFPVC MLGNRTLQNH NFDKCLKTDI VDNLTVTTQL WKLFCDGTGL NATCNKYFDE
NNVTMVQGIP GLTSGVISEN MWSKYGPLGM LVENKLTSYG GHDPSQDVYL PYVANDITTF
FTLLVGIYFP SVTGIMAGSN RSGDLRDAQK SIPIGTILAI ATTSFIYVTC VVLFGACIEG
VLLRDKFGDS VKGNLVIGTL SWPSPWVIVI GSFFSCCGAG LQSLTGAPRL LQAIARDGIV
PFLQVFGHGK ANGEPTWALL LTAGICEIGI LIASLDAVAP ILSMFFLMCY LFVNLACAVQ
TLLRTPNWRP RFKYYHWALS FLGMSLCLAL MFISSWYYAI VAMAIAGCIY KYIEYRGAEK
EWGDGIRGLS LNAARYALIR LEEAPPHTKN WRPQLLVLLN LDSDQGVKHP RLLSFTTQLK
AGKGLTIVGN VIEGTYLTKE AEAKKAEQNI KSSMSAERTK GFCHVVVSSN LRDGFSHLIQ
SAGLGGMKHN SVLMAWPGTW KQSNDPQSWR NFIETIRETT AAHQALLVAK NVDSFPTNQD
RLGEGTIDVW WVVHDGGMLM LLPFLLRQHK VWRKCKMRIF TVAQMDDNSI QMKKDLQMFL
YHLRLDAEVE VVEMQDNDIS AFTYEKTLMM EQRSQMLKQM HLSRTERERE IQSITDESRS
SIRRKNQGDA ENSNLSRQSS AAEDTQEDEA QLIHDRNTAS HATINDKADS GPERVHMTWT
KDKLFTERNR NRECNTNVAV RDLFNMKPEW ESLNQSNVRR MHTAIKLNEV VVNKSQGAHL
VLLNMPGPPK NRGGDENYME FLEVLLEGLN RALLVRGGGR EVITIYS
//
