ID A0A3Q1GAN0_9TELE Unreviewed; 985 AA.
AC A0A3Q1GAN0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A5 {ECO:0000313|Ensembl:ENSAPOP00000015130.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000015130.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000015130.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q1GAN0; -.
DR Ensembl; ENSAPOT00000023773.1; ENSAPOP00000015130.1; ENSAPOG00000018728.1.
DR GeneTree; ENSGT00940000157488; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 417..436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 456..480
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 500..522
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 657..675
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 705..724
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 745..769
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 805..824
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 831..850
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 882..913
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 111..342
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 387..883
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 985 AA; 112021 MW; 8CBFA1F0E0D17530 CRC64;
PVPRGYRRKR RRRRSSREAA DMDRDRRYSH QRHHEHDHYR DIDIEEGLMD SAEQSLQDIM
SPAAERLRYI LSEDDDMHTP TLFTEMDTLQ REGDELEWKE SARWVKFEEK VEEGGERWSK
PHVSTLSLHS LFELRTCLQT GTVLLDLEGY SLPQIVEEGM ISPDLREKIS FVLLRRHRHQ
TKKPIHRSLA DIGKSSSSTS ECPCLCHAQS RSMNDIADTP SSDQLKNKFM KKIPRDAEAS
NVLVGEVDFL NKPFVAFVRL AQATTLGGLT EVPVPTRFLF ILLGPQGKAK SYNEIGRAIA
TLMVDDLFSD VAYKARDRED LIAGIDEFLD EVIVLPPGEW DPKIRIEPPK KVTSADKRKS
VFSLNELGQM NGTAGGAGGM AEDEEIFCGG LYLDIKRKLP WIPSDFYEGF HIQSISAVLF
IYLGCITNAI TFGGLLGDAT DNYQGVMESF LGTALAGSVF CLFSGQPLII LSSTGPILIF
EKLLFEFSKN NSIDYMELRL WIGIHSCLQC FILVATDASY IIKYMTRFTE EGFSSLISFI
FISDAIKKMV GSFKYYPINT DFKPDYVTTY KCEFPMPDNS STVSGLNVTA LDWSQLSKKE
CLKYGGSLVG KSCKFVPDLA LMSFILFFGT YSMTVSLKKF KFSRYFPTKL RKLISDFSIF
MSIMTFVGLD MLMGLKTPKL IVPTEFKPTR PDRGWLVMPF GKNPWWIYLA SFVPALLVTI
LIFMDQQISA VIVNRKENKL KKGCGYHLDL FWVGVLMAAC SFMGLPWYVA ATVISIAHID
SLKMESESSA PGEQPQFLGV REQRVTGILV FALTGVSIFL APVLKFIPMP VLYGVFLYMG
VASLSGIQFW DRIKLYMMPS KHQPDYSYLR HVPLRRVHLF TLIQIMCLAV LWILKSTFLA
IIFPVMILGL MVVRKMLDMV FSRHDLAWLD DLLPEKEKKK KDDDKKKGKG KEKEKEKKKS
KADDSEEEVR NSILCCPLQD NWVMT
//
