ID   A0A3Q1GB03_9TELE        Unreviewed;       672 AA.
AC   A0A3Q1GB03;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000027313.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000027313.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A3Q1GB03; -.
DR   Ensembl; ENSAPOT00000001481.1; ENSAPOP00000027313.1; ENSAPOG00000011833.1.
DR   GeneTree; ENSGT00940000165986; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF36; ANOCTAMIN; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        226..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        257..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        330..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        374..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        415..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        514..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        558..584
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        604..625
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          209..637
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   672 AA;  76488 MW;  D63C07927B352303 CRC64;
     PVSGGEKVQS KLSAASIGPD WTKVRCPCCV SDRVEPLVLV KLGEKVGPET KRWIIRVIGA
     SQKDGGAALL AHPGEDASGD IIVVSAPRCT LLRATEELGL CKIYRNGDME AFSYSDRDNF
     KDSGTMFLTL AECQYIVKYE LDGLRAQRDL RIPGLPDSCT LHNRDNIWQK LRSFGVIVDT
     FPLHNPDKLK NLSEAWYSGN QLAQPLDSVN EYFGSSVAFY FSFLDFYTWS LLPPALLGLT
     ITYFSDIEGD SEPPVSGHML QAVFSMLWST VVMELWKRRS SSLSYRWGTL HLAERFAEPR
     PGFHGDLGVN PVTGRVEPLF PEWQRDLRMA LVSVPVVGLF LGLVVLGMMC FYWAEAQVQH
     LHNDWDSLLS QTLLYMPSVL HIVYTNMLAT VYKTVAQSLT EYENHREESA FQNHLTAKVL
     VFTFFNYFAV LFHIAFFKQD VPLLRKRLAS LLIVTQLINQ VTEVVIPFLV DRFISAPHRT
     QSEDDPQEEK FRNQGTLPTF PGLFAEYIEL LVQFGYLSLF SCVFPLTAVL LLLNNLTEIR
     SDAYKICKLF RKPFSPPAAN MGVWQIAFEV LSFVSVVSNC WLLLLSPRLQ DMFQEGGMSS
     TNVLLLAVLV EHVLILIKVI MAVLIPDEPD WIRKKREHIE YSSMQALRQK KSTRINRRTQ
     KYRSCRQLYR HL
//