ID A0A3Q1GBN8_9TELE Unreviewed; 753 AA.
AC A0A3Q1GBN8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Calcitonin receptor {ECO:0000256|ARBA:ARBA00017333};
GN Name=CALCR {ECO:0000313|Ensembl:ENSAPOP00000026579.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000026579.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000026579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with GPRASP2. {ECO:0000256|ARBA:ARBA00011681}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC {ECO:0000256|ARBA:ARBA00005314}.
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DR AlphaFoldDB; A0A3Q1GBN8; -.
DR Ensembl; ENSAPOT00000003406.1; ENSAPOP00000026579.1; ENSAPOG00000010539.1.
DR GeneTree; ENSGT00940000155380; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004948; F:calcitonin receptor activity; IEA:InterPro.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IEA:UniProt.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15274; 7tmB1_calcitonin_R; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 4.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001688; GPCR_2_calcitonin_rcpt.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR PANTHER; PTHR45620:SF8; CALCITONIN RECEPTOR; 1.
DR PANTHER; PTHR45620; PDF RECEPTOR-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF02793; HRM; 4.
DR PRINTS; PR00361; CALCITONINR.
DR PRINTS; PR01350; CTRFAMILY.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00008; HormR; 4.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 4.
DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 4.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 4.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..753
FT /note="Calcitonin receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018712611"
FT TRANSMEM 483..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..112
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 161..245
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 260..344
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 390..474
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 484..731
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 753 AA; 86779 MW; 44E15481EE4EF179 CRC64;
MRLADSFWIF WFLLVCRAAA GTEPISNPSF SPGQGITEGQ SEQAMSQGQC LELSKKDQQE
NRTGVFCAHM WDDLLCWEEA PAGTSVTQNC PDQSDLESAE KVTKYCDISG NWVQIGSTCK
PALKDKSEKE IPDLLRDAAG EHTTEAMRVS TEQNILENEK KCLEKMKTDP PYNKSGLYCS
RTWDGWLCWD DTPAETYASQ NCPDYFVDFD STEKATKYCR ADGQWFHHPG SNKIWTNYTL
CATTHEMRLN KPKMLENEYK CLLKINKDPP LNKGELRCSR NWDGWLCWDE TPAGNLASQN
CPDSPSDLDS TEKATKYCGE DGQWFRHPES NMTWTNYTLC AFNTKERLKA AAQFSRDAEV
ESTNEATVSP LVNREEKEVV RKKILDSQYK CFEKMNRDPP YNKSGLHCSR NWDGWLCWDD
TPAGTYTSQN CPNYFDDFDP TEKATKYCGE DGQWFRHPDT NRTWSNYTLC NENTQAKLKS
AYILFYMAIV GHALSIASLL ISLAIFFYFR SLSCQRITLH KNLFCSYVLN SALTIIYLVG
VVNNPHLVAR NPVGCKVLHF FHMYMLGCNY FWMLCEGIYL HTLIVVAVFA EEQHLHWYYL
LGWGFPLVPV SIHAVARRKY FDDNCWMSVD THLLYAVHGP IVAALLVNLF FLLNIIRVLV
TKLRDTHRAE SNMYMKAVRA TLILVPLLGI QFVIFPWRPE NRLAGEVYEY IMHILMHYQG
LLVATIFCFF NGEVKLVMHV HILALWLPYR EQH
//
