ID A0A3Q1GCC9_9TELE Unreviewed; 2452 AA.
AC A0A3Q1GCC9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Neuron navigator 2 {ECO:0000313|Ensembl:ENSAPOP00000026834.1};
GN Name=NAV2 {ECO:0000313|Ensembl:ENSAPOP00000026834.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000026834.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000026834.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR Ensembl; ENSAPOT00000002736.1; ENSAPOP00000026834.1; ENSAPOG00000010965.1.
DR GeneTree; ENSGT00940000155663; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR CDD; cd21285; CH_NAV2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF6; NEURON NAVIGATOR 2; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT DOMAIN 23..130
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 132..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 200..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 908..1148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1404..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1915..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2389..2452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1629..1712
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 132..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..453
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 908..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1068
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1428..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1463..1477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1514..1547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1730..1777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1814..1842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1916..1951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2419..2452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2452 AA; 260142 MW; 111786B318BA858F CRC64;
METGAEASPQ QHPRRKPVLH GLEDQKRIYT DWANHYLAKS GHKRLIKDLQ TDVTDGVLLA
EIIQVVANEK IDDINGCPKS RSQMIENIDA CLSFLAAKGV NIQGLSAEEI RNGNLKAILG
LFFSLSRYKQ QQQQAQRQNS QPALPAQSQS AHPPLSQQSS APAQLGHPPH GTPALPAQKA
AQAEMQSRDG CQSKLLKFSL GQKKTSRLPG PTTRVSTAGG DIPPRGSVSA AGNRRSQGFS
DKTKANSHLN KDSSEGMTSQ PSVMTEHAPS SAVTVSSSTS IPATTSTLIP PSSSTAIPQP
NSNSKPWRSK SASSKHTSSN SPTSTSPSPT AMQSVKQEKD TSSKGAPSTE APPKAVTQKS
MLEKLKLFNS KGGSKSSTTS SNGVLAQMDN AAPGRQPGVG QVERAETGSN TDPLEEDDGN
VRPGLNGTSN GTAFGAAPSA GTTVSTTASS PKIALRGIAQ RTFSRALTAK KGSVKGPEKD
KERGKEKEKD KDKGKEVGKR TSVPDRTELR GEESKDEAAS TAVDADGSNK RTSKIASFIP
KGGKVAKKES STTAHSGIPK PGGKAPGVGG KASSVKEAGE RPRSMRLGGG LAMHRGPLDR
DRDSRHSSST SSLASTEGKS SAAPVAGGGT TQSTASNTVS VQLPQTQQHH SHPNMATVAP
FMYRSQTDGE GTVNAETGSG GRGGDVSFTK TSQTSIEDLS GEDPETRRLR TVKNIADLRQ
NLEETMSSLR GTQVTHSTLE TTFDSSVTTD ISSGGGSGGG SGNNSGGSRS ILSLTSARPS
LSSWRLGQSS PRLQAGDAPS LGNGYGGRAV GSQGGRYLYP GHLRRQLAGR GGALCSVELG
DRAGEDIDLD GITMEVTGYM SDGDVLSKNA VRTDDVTSGY MTDGGLGLYT RRLNRLPDSM
AAVRETLHRN TSSGQGDADS WDDSSSVSSG ISDNIDTDDI NTSSSISSYA NTPAAQRKGL
NAQPVTDAEK HSASTAVHQS WSGDEVKRPD GGSDSGVRME PGSKWSRRNP SDISDESDKG
GSGRKTPSVS HTGSWRRGMS TQVGVTSPRT KSTGSTGSTG SVGLKTHSSG KTDDVKVSEK
GRLSPRANGL HRSPSDAGRS SGDEAKKQSI SSSRTPTTNT LTHTVSDPHS QTHTLTSRTP
TSTFGFKKQG PGMVTMVTAS GATITSGSAT LGKMPKSGGR SLSGGLKAGG QDGGSILGHH
DDGFLPMSAR STLQYRSLPR PSRSGAAARN GNRSSTSSIE AAVLSVTSHG KNSISLAKAN
GSAGLLANQT DREKGVSDID NLRSGAAMQS GGAATVPLTG RQQVSSPTLR RLFGGKPSKQ
APVTTAENMK NSTVISNPHA TMNHVATVLE SPDGGLAGVD MDTSSSLFGG RALGSGMGTL
GSEQASSPGS VYSSTGPSNS LTWGTTFSSS SVPSREGTLG GHGGTGSVGF PSVSSMHTSS
ESIDMSLGSA GGGGGLSTHR EDTLSALGRT GSVKTGMSES GPHCGRNTLP KKGLRYGPSP
QLRGHEEARD WLRSHSTSGL QDSASNSPFS PGSSLTSPSG TRFNFGQLAS SPTSAAQINL
AGMRTNSLTN QDVPFDPCGD NRLRNSCMSL DEKTRTMSRS GSFRDGFEEV HGSSLSLVSS
TSSIYSTNEE KSQSEIRKLR RELDASQEKV SALTTQLSAN AHLVAAFEQS LGNMTIRLKS
LTLTAEQKDS ELNELRKTIE LLKKQNAVAQ AAINGVINTP ELAPKGDRTA GTNGSPQQQH
QQQNQPPDLR IRRQHSSDSV SSVASATSHS SVGSNMDADA KNKKKNKKNW LRSSFKQAFS
KKKSPKSASS HSDIEEMTDS SLPSSPKLPH NGTSGTGHML RNTHSNTLLS ECLDSEAETV
MQLRSELREK EMKLTDIRLE ALSSAHQLDQ LREAMNRMQL EIEKLKAEND RLKLENQGSR
TGSQASISSS PPPHTHSQNP GPGPGLSQHS LNLTTSESTS LDMLLDDTGG EGGMRKEGRH
VKVVVSLDED RKWGEEGRTR HFLIGCIGVS GKTKWDVLDG VVRRLFKEYI THVDPVSQLG
LSSDSVQGYN IGEIHRPSSP SAAHTPELLP CGYLVGDNTI NIQLKGVSSE NVDSLVFDTL
IPKPMLQRYV SLLKEHRRVI LSGPSGTGKT YLANQLSRHL LLLEGRPLTP NAVVTFNVDH
KSSKELRQYL SGLAEQCSSV PGSDSPLVVI LDNLHHVSSL GEIFNGLFNC NYQHCPYIIG
TMSQATSSAP NLQLHHNFRW VLCANHMEPV KGFLGRYLRR KLIETEIGSR TRNMELVKII
DWVPRVWHHL NRFLETHSSS DVTIGPRLFL SCPMDVEGSR VWFTDLWNYS IIPYMLEAVR
EGLQLYGRRA AWEDPAAWVI DSYPWSATPP PADWPPLLQL RPEDVGFDGY SAPREGVRKE
PPQSDSDADP LMNMLMRLKE AATSSSPQSY DSDSNSNSHQ DDILDTSLES TL
//
