ID A0A3Q1GLA0_9TELE Unreviewed; 5033 AA.
AC A0A3Q1GLA0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000028177.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000028177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR STRING; 80966.ENSAPOP00000028177; -.
DR Ensembl; ENSAPOT00000018119.1; ENSAPOP00000028177.1; ENSAPOG00000013635.1.
DR GeneTree; ENSGT00940000155288; -.
DR InParanoid; A0A3Q1GLA0; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4340..4363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4554..4574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4637..4659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4773..4793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4837..4855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4914..4937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..148
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 155..200
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 208..263
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 269..332
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 583..793
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1009..1205
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1338..1551
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1330..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1840..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3490..3512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4260..4301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4395..4472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4488..4522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4600..4619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3677..3704
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1848..1904
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1905..1928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3496..3512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4263..4296
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4403..4426
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4605..4619
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5033 AA; 569905 MW; 2B9D4A56FF703FFA CRC64;
HNDGGEGAAE NDDQVVLQCT ASVLKEQQIK LCLSCEGFGN RLCFLETTSN AQNVPPDLAI
CTFILEQSLS VRALQEMLAN TVDMTESSQG GGHRTLLYGH AILLRHHHSG MYLSCLTTSR
SLTDKLAFDV GLQEDATGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS SERYLHLSYA
SGDLMVDASF MQTLWNMNPI SSGCELAEGF LTGGHVLRLF HGHMDECLAI ATPEEGEEKR
RTASYEGGAV CSQARSLWRL EPLRISWSGS HMKWGQSFRI RHITTGRYLC LDEEKGLLVV
DPERANTKLS AFCFRASKEK VDVAQKRDVE GMGIPEIKYG ESMCFVQHVS TGLWLTYAAL
DAKAARLGMM KRKVILHQEG HMDDALTVSR SQTEESQAAR MIYSTTGLFR QFIKGLDSLS
GKSKSPVAVS LPLEGVILSL QDLIFYFRPP EEELEHEEKQ TKLRSLRNRQ NLFQEEGMIT
IVLECIDRLN VYNTAAHFSE FAGEEAAESW KEIVNLLYEL LASLIRGNRS NCALFCDNLD
WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR NHKVLDVLRS
LCVCNGVAVR SNQNLITENL LPGRDLLLQT NIVNYATSVR PNIFLGTCEG STQYKKWYYE
MMVDYVEPFV TAQATHLRVG WAMTEGYSPY PGGGEGWGGN GVGDDLYSYG FDGLHLWSGT
VARQVASPSA HTLAADDVVS CCLDLSVPSI SFRINGHPVQ GMFENFNVDG LFFPVISFSA
GVKARFLLGG RHGDFKFMPP PGYAPCYEAV LPRERMRIEP IKEYKHDFEG VRNLLGPTLS
LTHTSFTPCP VDTVQIVLPP HLERIREKLA ENIHELWAVT RIEQGWTYGT FRDDNKKLHP
CLVDFLSLPE PERNYNLQMS GETLKTLLAL GCHVGMGDEK AEENLKKIKL PKTYVMTNGY
KPAPLDLSHV KLTPNQNQLV EKLAENGHNV WARDRVRQGW TYSIVQDIVN KRNPRLVPYN
LLDERTKKTN RDSVNNAVRT LIGYGYNIEP PDQESTGHGL ENTRGDKVRI FRAEKSYAVT
QGKWYFEFEA VTTGEMRVGW ARPNVRSDTE LGADELAYVF NGNKAQRWHI GNEPFGRQWQ
SGDVVGCMID LTEMNIMFTL NGEMLISDSG SEMAFKDIEV GEGFIPVCAL GLSQVGRINL
GQNVSSLRYF AICGLQEGFE PFAINMKRDI TMWFSKSLPQ FVPVPTDHNH IELSRVDGTV
DSAPCLKLTH KTFGSQNANT DMMFLRLSMP VQFHETFKIP AGTTPLTRAL TIPEEEVVVV
EPDSEFEVLK KSASRKEQEE EKKEPSVSKE ISVENEKDSM SEKGKKKGFF SKAKKAAMTP
LAPPPAPPTV PRLVEDVVPD DRDDPEIILS TTTYYYSVRI FAGQEPSGVW VGWVTPDYHQ
FDPTFDLSKV RSVTVTVGDD KGNIHDSMKH SNCYMVWGGD LVSNQQTRFS QEDMVVGCLV
DLATGLMTFT ANGKEINTFY QVEPNTKLFP AVFIQPSSQN MVQLELGKLK NIMPISAAMF
RSERKNPVPQ CPPRLDVQML TPVIWSRMPN HFLNPEVGRV SERLGWMVEC TEPLIMMALH
IPEENRCIDI LELSERQDLM KFHYHTLMLY CAVCALGNNR VAHALCSHVD ESQLFYATEN
TYLPGPLRSG YYDLLISIHL ESAKRARLGT NREFIVPMTE ETLSIHLYPD AKKAHSLPGV
GLTTCLRPKL HFSSINFVGT DPDLYTLSPI FPLQELKTRA ISMLTEAVLD GSQAMRDPVG
GSVEFHFVPI LKLISTLLIM GIFNDDDTKH ILKMIDPNVF SGKEEEEGEG EKAEEGGEGE
EGKDEEEEEA ELEDEGVGEE EEELKELEKA EEEEAEPKEE GEEGEKEEGE AKGGKVDGEK
AEEEKEAEAV EAEAKEEEEG LEEGLLQMKL PESVKLQMCT LLQYFCDCEL RHRVEAIVAY
SDQFVQNIQS NQRVRYNQLM RAFTMSAAET ARKTREFRSP PQDQVLLLTN FKHGPEDEEC
PVPEEVRDTL GEFHSDLLLH CGIHIEEEAE EEEVDTSLRG RLLSLVDKVK NIRKKEEVEE
KPEAEEEPKL STLQELISHT MIHWAQESFI QNPGLVRMMF SLLHRQYDGL GELIRALPKA
YAINAVSVQD TMDLLECLGQ IRSLLIVQMG PEEERLMIQS IGNIMNNKVF YQHPNLMRAL
GMHETVMEVM VNVLGGGGDS KEIRFPQMVT NCCRFLCYFC RISRQNQRSM FDHLSYLLQN
SGIGLGMRGS TPLDVAAASC IDNNELALAL QEQDLEMVVT YLAGCGLQMC PMLLSKGYPD
IGWNPCGGER YLDFLRFAVF VNGESVEENA NVVVRLLIRR PECFGPALRG EGGNGLLAAM
EEAIKISEDP ARDGPTVKKD RRFMFGGEEQ HEENRVHLGN AIMSFYSALI DLLGRCAPEM
HLIQAGKGEA LRIRAILRSL VPIEDLVGVI SLPVQIPAYG KESQIIEPKM SASFVPDHKA
SMVLFLDRVY GIDNQDFLLH VLEVGFLPDM RAAASLDTVA FSTTEMALAL NRYLCSAVLP
LLTKCAPLFA GTDHRAIMID SMLHTIYRLS RGRALTKAQR DVIEECLMSL CKYLRPSMLQ
HLLRRLVFDV PILNEYAKMP LKLLTNHYER CWKYYCLPNG WANFGVTSEE ELHLSRKLFW
GIFESLAHKK YDAELFKIAM PCLCAIAGAI PPDYVDASYS SHTEKKASVD AEGNFDPKPV
ETTNTIIPER LDAFINKYAE HTHDKWAFEK IQNNWTYGEL LDENAKTHPM LRPYKTFSEK
DKEIYRWPIK ESIKAMLAWE WTLEKAREGE GEVEKKAVTR KISQTAQATY DPSHGYNPQP
IDIAGMALSR ELQSMAEQLA ENYHNTWGRK KKLELQAKGG GTHPLLVPYD TLTAKEKARD
REKAQDLLKF LQLNGYAVTR GLKDMEQDIS SIEKRFAYGF LQKLLKWMDI AQEFIAHLEA
VVSSGRVEKS PHEQEIKFFA KILLPLVNQY FKNHCLYFLS TPAKVLGSGG HSSNKEKEMI
ASIFCKLAAL VRHRVSLFGT DASAVVNCLH ILSRSLDART VMKSGPEIVK AGLRQFFESA
ADDIEKMVEN LKLGKVSSRN QVKGVSQNIN YTTTALLPVL TSLFDHIAQH QFGDDVMMDD
LQISCYRLMC SIYSLGTVKT PHAEKQRPAL GECLAHLAAA MPVAFLEPAL NEFNTFSVYT
TKTPRERSIL GLPNQVEELC PDIPELEVLM KEIHDLAESG ARYTEMPHVI EITLPMLCNY
LPRWWERGLE NFPELEGQLC TSVTSEHLNQ LLGSIMKIVV NNLGIDEASW MKRLAVFAQP
IVSRAKPEML KSHFIPTMEK LKKRSGKVVA EEDQLRMEGK TEVDSENGTI RDEFAVLCRD
LYALYPLLIR YVDNNRARWL TCPDPDAEEL FRMVGEVFIF WSKSHNFKRE EQNFVVMNEI
NNMSFLTADS KSKMTKSGGS EQERTKKKRR GDRYSVQTSL IVAALKKMLP IGLNMCSPAD
QELINVAKIR YSLKDTDEEV REFLNNNLHL QGKVEDPAMR WQMSLYKEMS GKAEDAEDPE
KVVKRVQEVS AVLYHIEVTE HPFKSKKMVW HKLLSKQRRR AVVACFRMTP LYNIPTHRAT
NMFLDAYKRN WLETEGYSFE DKMIDDLSKA MEEEEEEEEE TESKPDPLHQ LILHFSRTAL
TEKTKLDVDH LYMSYADIMA KVRLLDVRGA VQLVLAGLQL CRFCSAPQEK EMEKQRLLYQ
QSRLHNRGAA EMVLQMISAC KGEPGAMVSS TLKLGISILN GGNSDVQQRM LDYLKDKKDV
GFFLSVQALM QTCSVLDLNA FERQNKAEGL GMVSEEGTNE KVMADDEFTC DLFRFLQLLC
EGHNNDFQNY LRTQTGSTTT INVIICTVDY LLRLQESISD FYWYYSGKDI IDEPGKRNFS
KAMTVAKQVF NSLTEYIQGP CTGNQQSLAH SRLWDAVVGF LHVFAHMMMK LAQDSSQIGL
LKELLDLQKD MVVMLLSLLE GNVVNGTIAR QMVDMLVESS SNVEMILKFF DMFLKLKDIV
ASDAFRDYVT DPRGLISKKD FSKAMDSQKQ YSPSEIQFLL SCSEADENEM INFEEFADRF
QEPAKDIGFN IAVLLTNLSE HVPHDTRLQN FLEQAESVLN YFRPFLGRIE IMGASRKIER
IYFEISEANR NQWEMPQVRE SKRQFIFDVV NEGGESEKME MFVNFCEDTI FEMNIAASIS
EPEGEGAEEE DDEEEEEGGG DEGGGESGEG EEGNGEGEAP ESTSAFADFL KSVVNFFNMF
TFRNLRRQYR KLRKMTIKEM VIGLATFIYT ILMGILIFVY SICKGFFTLI WKALFGGGLV
EGAKKMTVTE ILASMPDPTQ DEVHGDLPPE PGAREVQDAD GGMDHLDTVE GEEEEEDGEE
REGGRLPGFN APGGLGDFGE TTTEEPPTPE GTPLLKRKLF LCIFSSTENG EKAEKPEPEP
EAKEEEPAVE EEETKTVKTK AKKDKKHAEE GFELWNELEV QRIKFMNYLS RNFYNLRFLA
LFIAFALNFI LLFYRVSDSP PGEEEFEGSG LFEGSGLFEG SGAEEDGSGL EDGGEDDDEE
GPLYYFLEES TGYMEPAMAF LGIVHTIISF LCIIGYNCLK VPLVIFKREK ELARKLEFDG
LYVTEQPEDD DIKGQWDRLV LNTPTFPNNY WDKFVKRKVL DKYGDIYGRE RIAELLGMDL
ASLDVSAMTH EKKPEPDTSM FSWITSIDIK YQIWQFGVVF TDTTFLYLVW YMLMSLLGHY
NNFFFAAHLL DIAMGVKTLR TILSSVTHNG KQLMMTVGLL AVVVYLYTVV AFNFFRKFYN
MSEDEDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDEYELYRV FFDITFFFFV
IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG SDYFDTTPHG FETHTLEEHN
LANYMFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLG
//
