ID A0A3Q1GMC1_9TELE Unreviewed; 340 AA.
AC A0A3Q1GMC1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Cathepsin S-like {ECO:0000313|Ensembl:ENSAPOP00000030679.1};
GN Name=CTSS {ECO:0000313|Ensembl:ENSAPOP00000030679.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000030679.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000030679.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q1GMC1; -.
DR STRING; 80966.ENSAPOP00000030679; -.
DR Ensembl; ENSAPOT00000022956.1; ENSAPOP00000030679.1; ENSAPOG00000017560.1.
DR GeneTree; ENSGT00940000155176; -.
DR InParanoid; A0A3Q1GMC1; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF525; CATHEPSIN S; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..340
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018652958"
FT DOMAIN 38..98
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 125..339
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 340 AA; 37799 MW; 71D9EFF11FD6C3CB CRC64;
DAPTEKPDSI LKMFRSLLFT ILCGFAAADT SSKMDQHWEL WKQTHNKVYF HQIEELGRRQ
IWEENLEMIN VHNLEASLGL HTYELAMNHL GDLTTEEIAG SLTGTVVPSD LDRNPSNFIW
VNTSLPDSLD WRDAGLVTEV KIQGSCASCW AFSAAGALEG QFKKTSGTLR SLSAQNLLDC
STKYGSSGCK GGFMTQAFQY VTENHGVDSD SSYPYTGKYG HCHYEPQYRA ANCSGFVFLQ
DGDEDALKVA LANVGPISVA IDASSRKFAF YHHGVYQDDS CSHNVTHAVL AVGYGTERGQ
DYWLLKNSWG VNYGDEGYVK MVRNRWSQCG IADYACFPII
//
