ID A0A3Q1GRG1_9TELE Unreviewed; 1042 AA.
AC A0A3Q1GRG1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040395};
DE AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042170};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000019790.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000019790.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Cell projection, filopodium
CC {ECO:0000256|ARBA:ARBA00004486}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Synapse, synaptosome
CC {ECO:0000256|ARBA:ARBA00034102}.
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DR AlphaFoldDB; A0A3Q1GRG1; -.
DR STRING; 80966.ENSAPOP00000019790; -.
DR Ensembl; ENSAPOT00000029762.1; ENSAPOP00000019790.1; ENSAPOG00000023358.1.
DR GeneTree; ENSGT00940000155318; -.
DR InParanoid; A0A3Q1GRG1; -.
DR OrthoDB; 2876516at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd17189; FERM_F1_FARP1; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF2; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599}.
FT DOMAIN 43..323
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 537..728
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 757..854
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 929..1026
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 119307 MW; 0673FE249C7FE808 CRC64;
MAQPDPEPMS SGAGQRLGAP ETLGISTLDP GHRPPALPPG RHVTIRVRML DDTEELFDIS
QKASGKMLFD LVCSHMNLIE GDYFGLEFQN HQKMMVWLDH IKPIIKQLRR PKHTTLRFTV
KFFPPDHAQL LEELTRYLFA LQIKQDLSCG RLTCNDSSAA LMVSHIIQSE IGDFEESQCR
SHLLNNNYIP DQMPLIDKIM EFHSKNIGLT PAESDYQLLE VARRLEMYGI RLHPAKDREG
TRLSLAVAHT GVLVFQGHTR INAFNWSKVR KLSFKRKRFL IKLRPDLNSS YQDTLEFLMA
SRDCCKIFWK ICVEYHAFFR LFEEPKPKPK PVLFTRGSSF RFSGRTQKQV IDYVRESEFK
KIPFERKHSR VQYSSRVQHN SRLSPLPSPR HHEVPTESGV PGDRVDSPAR RHWKESVLVS
AEDPSVSRIT RASPSHQRNG HDDRAGSVSR TEERRGSTRQ AHPEHLNTGV ISNSPHLSAS
SGHSHAMVNG QKSLDLCSHS PDGRQPSPLT SPLLNDACSV RTDDEDEVRR KRFPTDRAYF
IAKELLTTER TYLKDLEVVT VSFQSAVGQD EVTPDSLKNT ILSTFEPLHK FHTGFLREVE
QRLALWEGRS NAHIKGDYQR IGDVMLKNLQ GLKPLTTNLN KQSEVLLELE KACKASRKLE
GLCRDFELQK VCYIPLNVFI LRPLHRLIHY KQILERLCKH YPATHVDFRD CRAALADVSE
VVEQLQGSLI KMENFQKLLE LKKDLMGVDN LVAPGREFIR LGCLSKLSGK GLQQRMFFLF
NDVILYTSRG MTPTNQFKVH GQLPLHGMTI RESEDEWGVP HAFTLVGQRQ SVVVAASSLT
EMEKWMEDIK MAIEMAKTSN GPSSDLLTTN LTDNKCLEDS SVEAESEDDM TAPHTSLERP
APHRGNTMVH VCWHRNTSVS MVDFSIAVEN QLSGNLLRKF KNSNGWQKLW VVFTNFSLFF
YKSHQDDYPL ASLPLLGYSV TIPSESENIH KDYVFKLHFK SHVYYFRSES EYTFERWMEV
IRSATVPSSR ARVLNSKEPH PH
//
