ID   A0A3Q1GSS8_9TELE        Unreviewed;       365 AA.
AC   A0A3Q1GSS8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Ras-related GTP-binding protein {ECO:0000256|RuleBase:RU367014};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000032679.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000032679.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Guanine nucleotide-binding protein that plays a crucial role
CC       in the cellular response to amino acid availability through regulation
CC       of the mTORC1 signaling cascade. {ECO:0000256|RuleBase:RU367014}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367014}.
CC       Lysosome {ECO:0000256|RuleBase:RU367014}.
CC   -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC       {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR   AlphaFoldDB; A0A3Q1GSS8; -.
DR   Ensembl; ENSAPOT00000026839.1; ENSAPOP00000032679.1; ENSAPOG00000020780.1.
DR   GeneTree; ENSGT00950000183031; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:UniProtKB-UniRule.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IEA:UniProtKB-UniRule.
DR   CDD; cd11385; RagC_like; 1.
DR   Gene3D; 3.30.450.190; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR006762; Gtr1_RagA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039400; RagC/D.
DR   PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR   PANTHER; PTHR11259:SF6; RAS-RELATED GTP-BINDING PROTEIN C; 1.
DR   Pfam; PF04670; Gtr1_RagA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU367014};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW   Lysosome {ECO:0000256|RuleBase:RU367014};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU367014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT   REGION          346..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  41131 MW;  B2E21957A569F5AE CRC64;
     MEFGFKSFKT SDGDKLTEKH GSVFSSSADR PRILLMGLRR SGKSSIQKVV FHKMSPNETL
     FLESTNKIYK DDISASSFVN FQIWDFPGQV DFFDPTFDSE MIFKGTGALI FVIDAQDDYM
     EALGRLHLTV SRAYKVNPDI NFEVFIHKVD GLSDDHKIET QRDVHQRAND DLADASLEKV
     HLSFYLTSIY DHSIFEAFSK VVQKLIPQLP TLENLLNIFI SHSGIEKAFL FDVVSKIYIA
     TDSSPVDMQS YELCCDMIDV VIDVSCIYGL MDDGGGCAYD RESLAIIKLN NTTVLYLKEV
     TKFLALVCIL REESFERKGL IEYNFHCFRK AIHEVFEVGG SPDGAAWRPE SSSGRKYGAV
     NGSAV
//