ID A0A3Q1GST2_9TELE Unreviewed; 410 AA.
AC A0A3Q1GST2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Forkhead box protein N3 {ECO:0000256|ARBA:ARBA00034870};
GN Name=FOXN2 {ECO:0000313|Ensembl:ENSAPOP00000033826.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000033826.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000033826.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a transcriptional repressor. May be involved in DNA
CC damage-inducible cell cycle arrests (checkpoints).
CC {ECO:0000256|ARBA:ARBA00034657}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A3Q1GST2; -.
DR STRING; 80966.ENSAPOP00000033826; -.
DR Ensembl; ENSAPOT00000034771.1; ENSAPOP00000033826.1; ENSAPOG00000022616.1.
DR GeneTree; ENSGT00940000159118; -.
DR InParanoid; A0A3Q1GST2; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20059; FH_FOXN3; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047404; FH_FOXN3.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR047119; FOXN2/3-like.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13962:SF19; FORKHEAD BOX PROTEIN N2; 1.
DR PANTHER; PTHR13962; FORKHEAD BOX PROTEIN N3-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT DOMAIN 121..208
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 121..208
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 44725 MW; 4473515AB81DC69D CRC64;
MGPIIGMSPD KKTEIPGMQE ERTGLRGVCG VGTLPEAECA SSPLATSVDR TGGTEDEELT
NLNWLHENLL QNFTLGGPEA QPSGSPLFDI EGDYGSSQGP SSSSSSSSHS RGRERDSLKS
KPPFSFSLLI YMAIEQSPSK SLPVKEIYGW ILEHFPYFSN APTGWKNSVR HNLSLNKCFR
KVERSLGKAN GKGSLWCVDP EYRPNLIQAL KKQHFPAAHA FCTPPASPPS ASSPPRHLFL
QGCSFKESDI DAATAMMLLN SAPGHHVDPC NSDSPLDLSR PDSVLVSSDP KQDHNYSSVA
LQRCSSRSSS SSLSSLDEGG CDRRQSHRAG SEGFHSDEDS DLWDERGVHQ TSRRPLAIKW
PTGKRARREV KPELDEELKE AAGSLLHLAG IRSCTEGSKR TVKSTKLNRK
//
