ID A0A3Q1GUZ4_9TELE Unreviewed; 585 AA.
AC A0A3Q1GUZ4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Wiskott-Aldrich syndrome protein family member {ECO:0000256|RuleBase:RU367034};
DE Short=WASP family protein member {ECO:0000256|RuleBase:RU367034};
GN Name=WASF1 {ECO:0000313|Ensembl:ENSAPOP00000034601.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000034601.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000034601.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Downstream effector molecule involved in the transmission of
CC signals from tyrosine kinase receptors and small GTPases to the actin
CC cytoskeleton. Promotes formation of actin filaments. Part of the WAVE
CC complex that regulates lamellipodia formation. The WAVE complex
CC regulates actin filament reorganization via its interaction with the
CC Arp2/3 complex. {ECO:0000256|RuleBase:RU367034}.
CC -!- SUBUNIT: Binds actin and the Arp2/3 complex.
CC {ECO:0000256|RuleBase:RU367034}.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|RuleBase:RU367034}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the SCAR/WAVE family.
CC {ECO:0000256|ARBA:ARBA00006993, ECO:0000256|RuleBase:RU367034}.
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DR AlphaFoldDB; A0A3Q1GUZ4; -.
DR STRING; 80966.ENSAPOP00000034601; -.
DR Ensembl; ENSAPOT00000030533.1; ENSAPOP00000034601.1; ENSAPOG00000000679.1.
DR GeneTree; ENSGT00950000182962; -.
DR InParanoid; A0A3Q1GUZ4; -.
DR OrthoDB; 616448at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:UniProtKB-UniRule.
DR CDD; cd22071; WH2_WAVE-1; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 6.10.280.150; -; 2.
DR InterPro; IPR028288; SCAR/WAVE_fam.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR12902; WASP-1; 1.
DR PANTHER; PTHR12902:SF8; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER 1; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00246; WH2; 1.
DR PROSITE; PS51082; WH2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|RuleBase:RU367034};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cytoplasm {ECO:0000256|RuleBase:RU367034};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367034};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 523..540
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 229..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..431
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..495
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 65074 MW; D7A6A7AEF556BC3D CRC64;
MPLVKRTIEP RHLCHTVLPR NIKNELECVT NISLANVIRQ LSSLSKYAED LFGELFNEAH
SFSFRVNSLQ ERVDRLSISV TQLDPKEEEL SLQDITMRKA FRSSTIQDQQ LFDRTSLPVP
LQETFHTCEQ PPPLNILTPY RDDGKEGLKF YTNPSYFFDL WREKMLQDTE DKRKERRKQK
LEMPYLVYPK SLIRALSETP PPFFTPPELQ DPRMYDQVYR YLDLPGQLKA IDRPPEPEKV
PRAPHDRKKE WQKLALGAEL AQDIPEDKHR EANGSAGYHD NRTQLYMEHL DGPFSLAALP
YSQMNELLNR TGDRMYSRPH DPPPPPPPMH PLGEIKPPSV ISSSSGFSDS RPQSPARTAG
LNSNTPPPPP PPLPPPPPPL PSSGLRGTPP PPIPPLPVQQ HPPAIPPPPA PLQIAPGVLH
PAPPPVAPPL HSSSPARLQQ VLDRGPCMGG SGTQSDGSIL PPPPPPPPLP LPGARSSSPC
PSGPPPVPAF PSAGAMASPP PHSLHDVGPK RHHPANLPPI SDARSVLLEA IRKGIQLRKV
EEQREQEAKH ERVGNDVATI LSRRIAVEYS DSEDESEFDE GDWME
//