ID   A0A3Q1H124_ANATE        Unreviewed;       738 AA.
AC   A0A3Q1H124;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Solute carrier family 12 member 8 {ECO:0000313|Ensembl:ENSATEP00000001254.1};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000001254.1, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000001254.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC       {ECO:0000256|ARBA:ARBA00010593}.
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DR   AlphaFoldDB; A0A3Q1H124; -.
DR   STRING; 64144.ENSATEP00000001254; -.
DR   Ensembl; ENSATET00000001276.2; ENSATEP00000001254.1; ENSATEG00000000857.2.
DR   GeneTree; ENSGT00940000160130; -.
DR   InParanoid; A0A3Q1H124; -.
DR   OMA; IMFIIQW; -.
DR   OrthoDB; 5403154at2759; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF6; SOLUTE CARRIER FAMILY 12 MEMBER 8; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        65..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        411..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        618..638
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        644..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          73..440
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   REGION          502..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..520
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   738 AA;  80712 MW;  79505443C95C7FF8 CRC64;
     METLPAGWTV HRGDKEGDGT GLLKEEVTDA NTNTHVHDLF HEDAQGLQHS SRPWWRIKLF
     VWEPVLFGTW DGVFTTCMIN IFGVVLFLRT GYLVGNTGVL LGMLLVSMVV LVALVTVMSG
     IGLCEHCGAG SGGIYSMIST VLGGRVGGTV GLLYVFGQCV AGAMYITGFS ESVAELLSLQ
     SQWAVRGMSA AVLLALLGIN LAGVKWIVRL QLLLLAVLAV STLDFVIGTF THLDPEHGFI
     GYSAELLRSN TMPDYSAGET FFTVFGVFFP AATGVMAGFN MSSDLQRPEH NIPVGTLAAV
     FTSWFLYLVF VFLLGAICTR EALRYDFLIA EKVSLVGFLF LLGLYISSLA SCMGGLYGAP
     RILQCIAEER VIPALAFLGK GKGPNRTPVA AICLTSLLTM AFIFIGQVNV LAPIVTINFM
     LTYSFIDYSY FSVAMTFQLQ SKEKDTPILA KGNQRRSTRQ SSRPLIETAL QNYGSGGESL
     QSKGTLLEFT KDMDQIFPPL SNVDAGAEKT SSMQELSSRR KSQKATAKQK LMNSFGLDLN
     SNMFSEQKGE EISSEPLYEE ADMQCGSGEL EARETNACHV EQDSPAEPRT GADGKAEHQT
     FEIQPMQDSC YAKFCNHWIA LIGALCSIVI MFVIQWLYAS ANILVALLLF FYIGKTSPGL
     PLGMAARFNF FTWLKSTVNS MCRSKRSPRD EIVVTPSLSG VGLKTKQLTE ENADFASRHR
     YHQSSFIGTD KMVQPPLH
//