ID   A0A3Q1H1D6_ANATE        Unreviewed;       375 AA.
AC   A0A3Q1H1D6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Arf-GAP with dual PH domain-containing protein 1 {ECO:0000313|Ensembl:ENSATEP00000001384.2};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000001384.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000001384.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q1H1D6; -.
DR   STRING; 64144.ENSATEP00000001384; -.
DR   Ensembl; ENSATET00000001406.2; ENSATEP00000001384.2; ENSATEG00000000891.2.
DR   GeneTree; ENSGT00940000155698; -.
DR   OrthoDB; 1022106at2759; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR   CDD; cd13252; PH1_ADAP; 1.
DR   CDD; cd01251; PH2_ADAP; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR037849; PH1_ADAP.
DR   InterPro; IPR037851; PH2_ADAP.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46021:SF5; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 2.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 2.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN          7..127
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          130..231
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          253..357
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
SQ   SEQUENCE   375 AA;  43832 MW;  92A1B91A5D391D81 CRC64;
     PHFKLSEHFN NMLKCRPSSS TRSQCITRFK PDWASLTLGV FVCQACSLLH RSIPHISRVK
     SVQDTWDASE VELMAAMGNN AAKAKYEQKV PAFYYRPTHT DCKLLREQWI RAKYERNEFE
     FIEKQEPYSA GYREGFLWKR GRDNGQFLSR KFILSEREGA LKYFNKQDAR DPKAVMKIET
     LNATFQPAKI GNPCGLQITY LKDNSTRNIF VYHSDAKEMV DWFNAIRAAR FHYLQVAFPG
     ASDEELVPKL TRNFMKEGFM EKTGPKHTEG FKKRWFTMDD RRLMYFKDPL DAYARGEVFI
     GSKENSYTVL AGLPPSTQGY HWNHGITIVT PERKFLFACE TEAEQRDWIA AFQRVINRPM
     RPQEYAVEAH FKHKP
//