ID   A0A3Q1H217_ANATE        Unreviewed;       869 AA.
AC   A0A3Q1H217;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=G-protein coupled receptor family C group 6 member A {ECO:0000256|ARBA:ARBA00039774};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000001549.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000001549.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A3Q1H217; -.
DR   STRING; 64144.ENSATEP00000001549; -.
DR   Ensembl; ENSATET00000001571.2; ENSATEP00000001549.2; ENSATEG00000000980.2.
DR   GeneTree; ENSGT00940000158416; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR   InterPro; IPR017979; GPCR_3_CS.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR   PANTHER; PTHR24061:SF5; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 6 MEMBER A; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF07562; NCD3G; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR   PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..869
FT                   /note="G-protein coupled receptor family C group 6 member
FT                   A"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030079306"
FT   TRANSMEM        532..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        569..591
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        603..629
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        641..664
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        687..709
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        721..743
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        749..771
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          533..793
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
SQ   SEQUENCE   869 AA;  97289 MW;  7964658E937ADE44 CRC64;
     MYFTFLPPMC VSYLFLSCMH CCHRFDVVGL VRALAMINAI EVMNKSPLLT DVNITLGYKI
     LDSCSDVNTA MRATEDIIEQ ANCHTGSNTT TCSQPVMAVV GSSISEISIA IARQLTLKMI
     PQISYSSTAA ILSDKSRFPS FMRTIPNDKY QTAAMVSLLS TYGWNWVGII TTDGDYGKSA
     LDNFMSQASE KGICVAFRSI LPQSVSSQDV DSAITQTAKI ILQNPKAQVI VSFAKPTHMK
     YLYQELKNQI LNAGQDMKSM RRVWVASDSW SSSRSVKGNL TLNDIGHVMG FTFKSGDLSS
     FNEYLSKLEA AWQDYEGHNP FLQELYVQLK SIKSSGDTEL VYKAVKTLKE YTQPNTILGV
     EMAVSALAKA VASICQSRDC KKPGTVQPWE LQVDFILRNK SYAFDRNGDI NLGYDVTMWR
     SDGDTKIYVQ DIVAEFHIDI NNFTYTNYST TQQFLDNIFS KCSNSCVPGE FKKTVEGQHT
     CCYECINCTE NYYSNKKDMD RCLACDTNVE WSPEGSSSCI PKKTLFFAWK DGFAVVLLTF
     CALGILMALL VSGLFLHQRG TPIVKAAGGP LNQVILFSLV MSYISAMLFV GQPNSLQCKA
     RQVLFGISFT LCVSCILVKT LQILLAFQFN PELQEVLRRL YQPYVIVSIC VALQVATCIC
     WLVHKSPFNY IIRNPTTLLE DCHEGSYLAF GVMLGYIALL AFVCFICAFK GRKLPQQYNE
     AKFITFSMLL YLISWLLFIP VYVTTSGVYL PAVEMVVILI SNYGILSCHF FPKCYIILFK
     KEQNTKSAFR KNLYEYSSKN KDSIWVCGSS VTDQWCSSQH STISASSISV PGANPVNPTP
     MTNCRDRSSC TSLHRELMTR HCLRRSISV
//