ID A0A3Q1H349_9TELE Unreviewed; 1096 AA.
AC A0A3Q1H349;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Aminoadipate-semialdehyde dehydrogenase {ECO:0000313|Ensembl:ENSAPOP00000034167.1};
GN Name=AASDH {ECO:0000313|Ensembl:ENSAPOP00000034167.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000034167.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000034167.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR AlphaFoldDB; A0A3Q1H349; -.
DR STRING; 80966.ENSAPOP00000034167; -.
DR Ensembl; ENSAPOT00000029704.1; ENSAPOP00000034167.1; ENSAPOG00000023212.1.
DR GeneTree; ENSGT00440000033811; -.
DR InParanoid; A0A3Q1H349; -.
DR OrthoDB; 76882at2759; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.480; -; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR44394; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44394:SF1; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF13360; PQQ_2; 2.
DR SMART; SM00564; PQQ; 7.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT DOMAIN 580..656
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 479..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1096 AA; 118637 MW; EF95A68FF5D9199B CRC64;
MSPRTLQQLV AAAASLYPDR AAVTYSGSVS GAPETLLYRD VAQLAGELSG ILQKNCSPNN
GLIGLYGGED VLIPVWILGI LQSSAAYVPL DPEAPGLLSA RVMSQCGLKY CAVKTDLLQQ
FQTALVEHAT VEVCVELPKF KLTLIRNGHL PVTEHKRGSR SPTSDDAVDA GCTDLAYVLH
TSGTTGLPKT VRVPHKCILP NILHLRSLFQ MRADDVVFLA SPLTFDPSVV DIFLALSSGA
RLLIVPALIK KMPNRLAQLL FKDHKATVLQ VTPTVLLRFG HRILKQDVLS SDSSLRVLAL
GGEACPSPAL LRSWRHEDNK TCIYNIYGVT EVSCWACCYQ IPESLLQSSN ITMPSVPLGS
PLMDTVVEVR DERGCVVTEG EGQVFIGGED RVCLLDDEDA VVAGTMRATG DWATVEDAQL
YYQGRKDRML KRNGKRLNLD GLQQLLLSLP QVDACAVGLY EGVRLLAFIV ASTSGDHTAA
STSSSVQQRA EQTPSALTEH QEKPPSSTEH HVEENGADRD LKRVILSQLS LLLPPHSVPD
TLVLVPALCL TPHGKVDMEA LVKIYERKRK PLKSSWEDAS KLKQTLQALW QDTLGLAADA
TLDEESNFLF SGGDSLKALR LSEDIHSAVG VTSPELLAVI LDGTFADVLH HVAKLTQMLS
PESISSPPSE AKKRRTDPPS VARVKKKRKD FTAAERFQVE KRAVKVIRRA GEIIELNFRN
TENNKSIQAD KLGEINSGNK HRDVDVGLSL SWSSDTGRCV DASPVLLVED EANQRSKTTV
FIGSHSHRIQ SLDLTTGSLL WERVLGDRIE ASVAVSHCGS LVIVGCYDAC VHFLCAKSGK
TRWTFETGDA VKSCPAVDPQ TGLVIVGSHD GNVYALNPQA RQCVWKRHCG GGAVFSSPHL
SSSLRRLYVA TLGGRLLCLN PGSGDVLWSY CTDVPLFSSP SSCSGHVVIG SVDGNICCIS
NSGKLLWRFL TKAPVFSSPC VTPDQQKLLC GSHDGRLYCL NCADGSLVWT FQTTGKVYSS
PCVFGGSAVG RTGALVGLAS TDGSVWILDG QNGQMLASFV LPGELFSSPV VWEQSLVIGC
RNDYVYCLKL TIEEKT
//
