ID A0A3Q1H4S9_9TELE Unreviewed; 779 AA.
AC A0A3Q1H4S9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Discs large MAGUK scaffold protein 4 {ECO:0000313|Ensembl:ENSAPOP00000023965.1};
GN Name=DLG4 {ECO:0000313|Ensembl:ENSAPOP00000023965.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000023965.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000023965.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1H4S9; -.
DR Ensembl; ENSAPOT00000009965.1; ENSAPOP00000023965.1; ENSAPOG00000006156.1.
DR GeneTree; ENSGT00940000157956; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF33; DISKS LARGE HOMOLOG 4; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 2.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 117..204
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 212..299
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 364..445
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 479..549
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 588..764
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 551..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 86147 MW; DDCCA2837E0A3473 CRC64;
MKGRTKLPSL CPCVKYRYQD EETPPLEHSP AHLAPGKSAE MLHMSDKNLA AMEAIHGYTP
HTHISPVKPV LMSTGHTPMY TSAVSTLGNT PPVVVNTDTL DGSPYVNGTE GEIEYEEITL
ERGNSGLGFS IAGGTDNPHV GDDPSIFITK IIPGGAAAQD GRLSVNDCIL FVNDVDVREV
THSQAVEALK EAGAIVRLYV LRRKPAAEKV TEIKLIKGPK GLGFSIAGGV GNQHIPGDNS
IYVTKIIEGG AAHKDGRLQI GDKILAVNNV CLEDVMHEDA VGALKNTAEV VYLRVAKPNN
LFLTNSYNPP DLTSTYSHMD TELSHPNYLG SDYPQALTPT SPSRFSPVLH GIMGDDDIPR
EPRRVLIHRG STGLGFNIVG GEDGEGIFIS FILAGGPADL SGELHKGDQI LSVNGVDLRM
ATHEQAAAAL KNAGQTVTII AQYRPDEYSR FEAKIHDLRE QLMNSSMGSG TTTLRSNPKR
GFYIRALFDY DKTADCGFLS QALGFKFGDV LHVLDCGDEE WWQARKVSPQ NEAEEVGFIP
SKHRVERKEW SRVNTKERDH GRDTLSTQGR DKTSHSYETV TQVEVHYARP IIILGPVKDR
INDDLLSEFP DKFGSCVPHT TRPKREYEVD GRDYHFVSSR EQMEKDIQSH RFIEAGQYNS
HLYGTSVQSV REVAEQQGKH CILDVSANAV RRLQAAQLHP IAIFVRPKSL ENVLEINTRL
TEEQARKGMD RALKLEQDFL ECFSAVVEGD SFEEVYHKVK TVIEEQSGPY IWIPTRERL
//
