ID A0A3Q1H5I7_9TELE Unreviewed; 944 AA.
AC A0A3Q1H5I7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Extracellular calcium-sensing receptor {ECO:0000256|ARBA:ARBA00039746};
GN Name=CASR {ECO:0000313|Ensembl:ENSAPOP00000024235.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000024235.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000024235.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3Q1H5I7; -.
DR Ensembl; ENSAPOT00000009302.1; ENSAPOP00000024235.1; ENSAPOG00000006738.1.
DR GeneTree; ENSGT00940000157596; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15282; 7tmC_CaSR; 1.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF358; EXTRACELLULAR CALCIUM-SENSING RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..944
FT /note="Extracellular calcium-sensing receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018790434"
FT TRANSMEM 520..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..699
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 711..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 520..783
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 799..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 801..829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 105453 MW; 3E2DB376EDB07E55 CRC64;
MRLLLYYVVL LGSSYVISTY GPHQRAQMTG DILLGGLFPI HFGVASKDQD LAARPESTQC
VRFNFRGFRW LQAMIFAIDE INNSSTLLPN ITLGYRIFDT CNTVSKALEA TLSFVAQNKI
DSLNLDEFCN CTDHIPSTIA VVGAAGSAVS TAVANLLGLF YIPQISYASS SRLLSNKNQY
KSFMRTIPTD EYQATAMADI IEHFQWNWVI AVASDDDYGR PGIEKFEKEM EERDICIHLN
ELISQYFEDH EIKALADRIE NSTAKVIVVF ASGPDIEPLI KEMIRRNITD RIWLASEAWA
SSSLIAKPEY LDVVAGTIGF ALKSGSIPGF KEFLQNVQPK KDSHNEFVRE FWEETFNCYL
EDSPRLQESE NGSTSFRPLC TGEEDITSVE TPYLDYTHLR ISYNVYVAVY SIAQALQDIL
TCTPGHGLFA NNSCADIKKM EAWQVPFSNC SEDCEPGTRK GIIDSMPTCC FECTECSDGE
YSNHKDASVC TKCPNNSWSN GNHTFCFVKE IEFLSWTEPF GIALAICAVL GIVLTAFVMG
VFVRFRNTPI VKATNRELSY VLLFSLICCF SSSLIFIGEP QDWTCRLRQP AFGISFVLCI
SCILVKTNRV LLVFEAKIPT SLHRKWWGLN LQFLLVFLCT FVQVMICVVW LYNAPPSSYK
NHDIDEIIFI TCNEGSVMAL GFLIGYTCLL AAICFFFAFK SRKLPENFTE AKFITFSMLI
FFIVWISFIP AYFSTYGKFV SAVEVIAILA SSFGMLACIF FNKVYIILFK PSRNTIEEVR
CSTAAHAFKV AAKATLKHNT ASRKKSSSIG GSSASSPSSS ISLKTNGNDC DRTSGKHRPR
VSFGSGTVTL SLSFDESRRS SLIGAAHIFG IMTDLDRSAR AAGQPSPLLT RKKSLYPQRH
KYSPAARPAC CMFKLQGRMI LDKMTRKHYM LGTSGTALVP AKKI
//
