ID A0A3Q1H810_9TELE Unreviewed; 455 AA.
AC A0A3Q1H810;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Sodium/potassium/calcium exchanger 1 {ECO:0000256|ARBA:ARBA00040585};
DE AltName: Full=Na(+)/K(+)/Ca(2+)-exchange protein 1 {ECO:0000256|ARBA:ARBA00042035};
DE AltName: Full=Retinal rod Na-Ca+K exchanger {ECO:0000256|ARBA:ARBA00042297};
DE AltName: Full=Solute carrier family 24 member 1 {ECO:0000256|ARBA:ARBA00042684};
GN Name=SLC24A1 {ECO:0000313|Ensembl:ENSAPOP00000024915.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000024915.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000024915.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in)
CC + 4 Na(+)(out); Xref=Rhea:RHEA:69967, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29103, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033627};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC24A subfamily. {ECO:0000256|ARBA:ARBA00005364}.
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DR AlphaFoldDB; A0A3Q1H810; -.
DR Ensembl; ENSAPOT00000007557.1; ENSAPOP00000024915.1; ENSAPOG00000007942.1.
DR GeneTree; ENSGT01030000234532; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004481; K/Na/Ca-exchanger.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR10846:SF36; SODIUM_POTASSIUM_CALCIUM EXCHANGER 1; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..203
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 304..444
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 252..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 51181 MW; B06E5CB382920CD1 CRC64;
LRVLGFTFSL FIHKTQTAEL QIPHTPTAAP TEPDEAPHVN GGYPKDIFSI EDRRRGWVIL
HIIGIMYMFV SLGIACNEFF VPALWVITDK LAISNDVAGA IVMAAGRSSP KFFTALIGAF
INHSNVGIGN IIGSAVYNIL FVIGICALFS WAVLHLTWWP LFRDVSFYIL HLILLIIFFL
DNVITWWESM MLVASYTTYV VFMKFNTHIV RAFRTQLHKD KGTVEVVALE ETEKVSSYVN
TFVMYLQEWM GQEDPDNDED NSKKRRSDSG KNEDENEVNQ EEEGKKDKPL SLEWPVRLGR
IKFYVVTFLA SILWINVFFY FMVWWAHQVG ETIRIPEEIL GLTILAAGTS IPDLIIGVTV
TRKGLGDMAV SSSVGKNIFD ITVGLPVPWL LYSSIHGFAP VAVSSNGLFC AITLLFFMLL
LLGFTMLLFY MIFVVICVTL QYGIIVCPVS IGNNG
//
