ID A0A3Q1HB46_ANATE Unreviewed; 147 AA.
AC A0A3Q1HB46;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Ubiquitin-conjugating enzyme E2 variant 2 {ECO:0000256|ARBA:ARBA00039474};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000004619.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000004619.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N
CC heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin
CC chains that are linked through 'Lys-63'. This type of poly-
CC ubiquitination does not lead to protein degradation by the proteasome.
CC Mediates transcriptional activation of target genes. Plays a role in
CC the control of progress through the cell cycle and differentiation.
CC Plays a role in the error-free DNA repair pathway and contributes to
CC the survival of cells after DNA damage.
CC {ECO:0000256|ARBA:ARBA00037093}.
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DR AlphaFoldDB; A0A3Q1HB46; -.
DR STRING; 64144.ENSATEP00000004619; -.
DR Ensembl; ENSATET00000004684.2; ENSATEP00000004619.1; ENSATEG00000003240.2.
DR GeneTree; ENSGT00740000115534; -.
DR InParanoid; A0A3Q1HB46; -.
DR OMA; NNIKMVL; -.
DR OrthoDB; 5245345at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR000608; UBQ-conjugat_E2.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR PANTHER; PTHR24068; UBIQUITIN-CONJUGATING ENZYME E2; 1.
DR PANTHER; PTHR24068:SF177; UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 2; 1.
DR Pfam; PF00179; UQ_con; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS50127; UBC_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265040}.
FT DOMAIN 12..147
FT /note="UBC core"
FT /evidence="ECO:0000259|PROSITE:PS50127"
SQ SEQUENCE 147 AA; 16354 MW; 89629BA121227A1F CRC64;
MAVAAVSGVV VPRSFRLLEE LEEGQKGGGD GTVSWGLADD NDMTLTHWTG MIIGPAKTVY
EGRIYSLKIE CGPRYPEHPP HVRFVNKINL SGVHSSNGLV DLKAVSSMSR WKNSYTIRTV
LQELRQHMMM KENNRLSQPP EGQVYGN
//
