ID A0A3Q1HCI5_ANATE Unreviewed; 1325 AA.
AC A0A3Q1HCI5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 {ECO:0000313|Ensembl:ENSATEP00000006317.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000006317.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000006317.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSATET00000006421.2; ENSATEP00000006317.2; ENSATEG00000004373.2.
DR GeneTree; ENSGT00940000159456; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22903:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 576..670
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 684..792
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 829..983
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 994..1325
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 233..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 38..112
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 262..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1325 AA; 148942 MW; 42DCCCB1F9E5B9C9 CRC64;
MESGGSGPVG AASVDWQKRC VALEMQLLRF RLQAGKIREL LAEKMQELEQ RVMEADRRAE
SAEKQVIHVM EEKLKSANIQ TSESESSLYR KYQDLTNQVQ EKDAVIKRLE VQLEKQVRIE
AQEAKIIEEK AAKIKDWVTF KLREMEQENQ QLKMANLKQT EQIMLLQDKL QCEYHLCISI
KTEVFCSIPL AFVHIWSVSQ MSLICPLPDG KRLPEQISKG ICLGDFAAHD ALSQGRSREG
PSSPVSISGP DLPVGPEGQA GCSDRDNSSD ELNSKFRSQC LHSSSSSSSS SSAYEMPLIH
QSGTSMTLPK VRTPLTPRDS IQLVKKHYSQ PQPSLDRLHH LNVNIDIITG TTTSPFSQVV
EETDIDYGLP DSMDGVVEGP ETDDLSQDGV SFVGLAEELE RLDPEALKPP TPPLHRFPSW
ESRIYAVAKS GMRVSEASPG VRGPGRGSIL PQYPAAGPFT QLIYKNINVP VYTTLKGKAT
QISSVPLPDD DSGSEDDSSS LVSLRTSILS PDRKSSVPGS PRAVKRGVSM SSISSESDYA
IPPDAYSLDS DYSEPEHKVQ RTSSYSCEST GPVSEMLEKS GYLLKMGSQV KAWKRRWFIL
RNGEILYYKS PSDVIRKPQG QIELSSSCCI VRGEGAQTFQ LITEKKTFYL TADSPNILEE
WIRVLQNILK VQASSQVTVE TTAKPTVRGW LTKVKHGHSK LVWCSLVGKI FYYYRNQEDK
LPLGQLQMRE ALVQEVDRSC DSDEDYEAGS RGFLSSHCTL VVQPRDQSPT YLLIGTKQEK
DTWLYHLTVA AGSSATFKVG TEYEQLIGKL LDAEGDPESA LWRSEALSFC KEGLRSPLTT
LPSEALQTEA LKLFKSCQLF INVLVESPSV DYHTSLAQHA LQVCLTHPEL QNEMYCQLIK
QTNRRTTHNY SLTQCWQLLS LCVALFLPQQ HILWYLRQYL QRNADPSSEV GKYAVYCQRS
VERTLQNGER EARPSRMEII SILLRNPYHH SLPFSIPVHF MNNTYQVVGF DGSTTVEEFL
NTLNQRIGMR KPQLSGFALF TDDPTGKDLE HCLQPSAKIC DVISKWEQAL KELHPGKNEG
TRIVRLTYKS RLCFRSQVKG ETERERLLLA YQVNDEVHHG HFPVNKELAL EVAALMAQVE
HGDLERTAAS SPTGSPQPKS QLILLQALER FYPKRYKQDC SSEQLRELTE RLATKWSMLR
GCSASECVRI YLTVARKWPL FGAKLFSAQP GVAGTIKFEH ALCLYVFHCT FHAGCIFQHT
LVTYPYQSVI TFGGYRDDFM VVTSHQTEPG VGKKSAEKLV FAMAKPKVCL LHLLSFYQTK
IVMYQ
//
